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CD133, a novel marker for human prostatic epithelial stem cells

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CD133, a novel marker for human prostatic epithelial stem cells. / Richardson, G.D.; Robson, C.N.; Maitland, N.; Lang, S.H.; Neal, D.E.; Collins, A.T.

In: Journal of Cell Science, Vol. 117, No. 16, 15.07.2004, p. 3539-3545.

Research output: Contribution to journalArticlepeer-review

Harvard

Richardson, GD, Robson, CN, Maitland, N, Lang, SH, Neal, DE & Collins, AT 2004, 'CD133, a novel marker for human prostatic epithelial stem cells', Journal of Cell Science, vol. 117, no. 16, pp. 3539-3545. https://doi.org/10.1242/jcs.01222

APA

Richardson, G. D., Robson, C. N., Maitland, N., Lang, S. H., Neal, D. E., & Collins, A. T. (2004). CD133, a novel marker for human prostatic epithelial stem cells. Journal of Cell Science, 117(16), 3539-3545. https://doi.org/10.1242/jcs.01222

Vancouver

Richardson GD, Robson CN, Maitland N, Lang SH, Neal DE, Collins AT. CD133, a novel marker for human prostatic epithelial stem cells. Journal of Cell Science. 2004 Jul 15;117(16):3539-3545. https://doi.org/10.1242/jcs.01222

Author

Richardson, G.D. ; Robson, C.N. ; Maitland, N. ; Lang, S.H. ; Neal, D.E. ; Collins, A.T. / CD133, a novel marker for human prostatic epithelial stem cells. In: Journal of Cell Science. 2004 ; Vol. 117, No. 16. pp. 3539-3545.

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@article{acd9e546706f48a1a7987119c19ab4e5,
title = "CD133, a novel marker for human prostatic epithelial stem cells",
abstract = "Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia. Stem cells remain poorly characterised because of the absence of specific molecular markers that permit us to distinguish them from their progeny, the transit amplifying cells, which have a more restricted proliferative potential. Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker. Here we show that a small population (approximately 1%) of human prostate basal cells express the cell surface marker CD133 and are restricted to the {alpha}2{\ss}1hi population, previously shown to be a marker of stem cells in prostate epithelia (Collins, A. T., Habib, F. K., Maitland, N. J. and Neal, D. E. (2001). J. Cell Sci. 114, 3865-3872). {alpha}2{\ss}1hi/CD133+ cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice.",
keywords = "stem cells, CD133, integrins, prostate, UROGENITAL SINUS MESENCHYME, HEMATOPOIETIC STEM, TISSUE RECOMBINANTS, NERVOUS-SYSTEM, IN-VITRO, EXPRESSION, DIFFERENTIATION, MEMBRANE, SURVIVAL, MOUSE",
author = "G.D. Richardson and C.N. Robson and N. Maitland and S.H. Lang and D.E. Neal and A.T. Collins",
year = "2004",
month = jul,
day = "15",
doi = "10.1242/jcs.01222",
language = "English",
volume = "117",
pages = "3539--3545",
journal = "Journal of Cell Science",
issn = "0021-9533",
publisher = "Company of Biologists Ltd",
number = "16",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - CD133, a novel marker for human prostatic epithelial stem cells

AU - Richardson, G.D.

AU - Robson, C.N.

AU - Maitland, N.

AU - Lang, S.H.

AU - Neal, D.E.

AU - Collins, A.T.

PY - 2004/7/15

Y1 - 2004/7/15

N2 - Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia. Stem cells remain poorly characterised because of the absence of specific molecular markers that permit us to distinguish them from their progeny, the transit amplifying cells, which have a more restricted proliferative potential. Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker. Here we show that a small population (approximately 1%) of human prostate basal cells express the cell surface marker CD133 and are restricted to the {alpha}2ß1hi population, previously shown to be a marker of stem cells in prostate epithelia (Collins, A. T., Habib, F. K., Maitland, N. J. and Neal, D. E. (2001). J. Cell Sci. 114, 3865-3872). {alpha}2ß1hi/CD133+ cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice.

AB - Stem cells are clonogenic cells with self-renewal and differentiation properties, which may represent a major target for genetic damage leading to prostate cancer and benign prostatic hyperplasia. Stem cells remain poorly characterised because of the absence of specific molecular markers that permit us to distinguish them from their progeny, the transit amplifying cells, which have a more restricted proliferative potential. Human CD133 antigen, also known as AC133, was recently identified as a haematopoietic stem cell marker. Here we show that a small population (approximately 1%) of human prostate basal cells express the cell surface marker CD133 and are restricted to the {alpha}2ß1hi population, previously shown to be a marker of stem cells in prostate epithelia (Collins, A. T., Habib, F. K., Maitland, N. J. and Neal, D. E. (2001). J. Cell Sci. 114, 3865-3872). {alpha}2ß1hi/CD133+ cells exhibit two important attributes of epithelial stem cells: they possess a high in vitro proliferative potential and can reconstitute prostatic-like acini in immunocompromised male nude mice.

KW - stem cells

KW - CD133

KW - integrins

KW - prostate

KW - UROGENITAL SINUS MESENCHYME

KW - HEMATOPOIETIC STEM

KW - TISSUE RECOMBINANTS

KW - NERVOUS-SYSTEM

KW - IN-VITRO

KW - EXPRESSION

KW - DIFFERENTIATION

KW - MEMBRANE

KW - SURVIVAL

KW - MOUSE

U2 - 10.1242/jcs.01222

DO - 10.1242/jcs.01222

M3 - Article

VL - 117

SP - 3539

EP - 3545

JO - Journal of Cell Science

JF - Journal of Cell Science

SN - 0021-9533

IS - 16

ER -