CD317 profiling distinguishes bone marrow stromal cell subtypes with distinct functional impact upon T cell proliferation and polarisation

Alasdair Gawain Kay; Andrew Stone; James Martin Fox; Paul Gilbert Genever

doi:10.1016/j.joca.2018.02.595

CD317 profiling distinguishes bone marrow stromal cell subtypes with distinct functional impact upon T cell proliferation and polarisation

Alasdair Gawain Kay, Andrew Stone, James Martin Fox, Paul Gilbert Genever

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

Purpose: The development of enhanced therapeutic interventions
using human mesenchymal stromal cells (MSCs) for regenerative
medicine is a priority in osteoarthritis research. MSCs are a heterogeneous
cell population with immunomodulatory and anti-inflammatory
properties. We have identified a novel biomarker (CD317) that allows
the isolation of MSCs subpopulations with tissue regenerative properties
(Y201, CD317-) and non-differentiating MSCs with an enriched proinflammatory
transcriptional profile (Y202, CD317þ) that make up an
average of 9% of the total MSCs population. We investigated the
immunomodulatory function of these subpopulations to understand
their role in disease processes and potential impact on regenerative
therapies.

Original language	English
Article number	556
Pages (from-to)	S296-S297
Number of pages	2
Journal	Osteoarthritis and cartilage
Volume	26
Issue number	Supplement 1
DOIs	https://doi.org/10.1016/j.joca.2018.02.595
Publication status	Published - Apr 2018

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Cite this

@article{2bfac6f0deef4f5b95b61b15f0de0939,

title = "CD317 profiling distinguishes bone marrow stromal cell subtypes with distinct functional impact upon T cell proliferation and polarisation",

abstract = "Purpose: The development of enhanced therapeutic interventionsusing human mesenchymal stromal cells (MSCs) for regenerativemedicine is a priority in osteoarthritis research. MSCs are a heterogeneouscell population with immunomodulatory and anti-inflammatoryproperties. We have identified a novel biomarker (CD317) that allowsthe isolation of MSCs subpopulations with tissue regenerative properties(Y201, CD317-) and non-differentiating MSCs with an enriched proinflammatorytranscriptional profile (Y202, CD317{\th}) that make up anaverage of 9% of the total MSCs population. We investigated theimmunomodulatory function of these subpopulations to understandtheir role in disease processes and potential impact on regenerativetherapies.",

author = "Kay, {Alasdair Gawain} and Andrew Stone and Fox, {James Martin} and Genever, {Paul Gilbert}",

year = "2018",

month = apr,

doi = "10.1016/j.joca.2018.02.595",

language = "English",

volume = "26",

pages = "S296--S297",

journal = "Osteoarthritis and cartilage",

issn = "1063-4584",

publisher = "W.B. Saunders Ltd",

number = "Supplement 1",

}

TY - JOUR

T1 - CD317 profiling distinguishes bone marrow stromal cell subtypes with distinct functional impact upon T cell proliferation and polarisation

AU - Kay, Alasdair Gawain

AU - Stone, Andrew

AU - Fox, James Martin

AU - Genever, Paul Gilbert

PY - 2018/4

Y1 - 2018/4

N2 - Purpose: The development of enhanced therapeutic interventionsusing human mesenchymal stromal cells (MSCs) for regenerativemedicine is a priority in osteoarthritis research. MSCs are a heterogeneouscell population with immunomodulatory and anti-inflammatoryproperties. We have identified a novel biomarker (CD317) that allowsthe isolation of MSCs subpopulations with tissue regenerative properties(Y201, CD317-) and non-differentiating MSCs with an enriched proinflammatorytranscriptional profile (Y202, CD317þ) that make up anaverage of 9% of the total MSCs population. We investigated theimmunomodulatory function of these subpopulations to understandtheir role in disease processes and potential impact on regenerativetherapies.

AB - Purpose: The development of enhanced therapeutic interventionsusing human mesenchymal stromal cells (MSCs) for regenerativemedicine is a priority in osteoarthritis research. MSCs are a heterogeneouscell population with immunomodulatory and anti-inflammatoryproperties. We have identified a novel biomarker (CD317) that allowsthe isolation of MSCs subpopulations with tissue regenerative properties(Y201, CD317-) and non-differentiating MSCs with an enriched proinflammatorytranscriptional profile (Y202, CD317þ) that make up anaverage of 9% of the total MSCs population. We investigated theimmunomodulatory function of these subpopulations to understandtheir role in disease processes and potential impact on regenerativetherapies.

U2 - 10.1016/j.joca.2018.02.595

DO - 10.1016/j.joca.2018.02.595

M3 - Meeting abstract

SN - 1063-4584

VL - 26

SP - S296-S297

JO - Osteoarthritis and cartilage

JF - Osteoarthritis and cartilage

IS - Supplement 1

M1 - 556

ER -