By the same authors

From the same journal

CD317 profiling distinguishes bone marrow stromal cell subtypes with distinct functional impact upon T cell proliferation and polarisation

Research output: Contribution to journalMeeting abstractpeer-review

Published copy (DOI)



Publication details

JournalOsteoarthritis and cartilage
DatePublished - Apr 2018
Issue numberSupplement 1
Number of pages2
Pages (from-to)S296-S297
Original languageEnglish


Purpose: The development of enhanced therapeutic interventions
using human mesenchymal stromal cells (MSCs) for regenerative
medicine is a priority in osteoarthritis research. MSCs are a heterogeneous
cell population with immunomodulatory and anti-inflammatory
properties. We have identified a novel biomarker (CD317) that allows
the isolation of MSCs subpopulations with tissue regenerative properties
(Y201, CD317-) and non-differentiating MSCs with an enriched proinflammatory
transcriptional profile (Y202, CD317þ) that make up an
average of 9% of the total MSCs population. We investigated the
immunomodulatory function of these subpopulations to understand
their role in disease processes and potential impact on regenerative

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations