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CD317 profiling distinguishes bone marrow stromal cell subtypes with distinct functional impact upon T cell proliferation and polarisation

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JournalOsteoarthritis and cartilage
DatePublished - Apr 2018
Issue numberSupplement 1
Volume26
Number of pages2
Pages (from-to)S296-S297
Original languageEnglish

Abstract

Purpose: The development of enhanced therapeutic interventions
using human mesenchymal stromal cells (MSCs) for regenerative
medicine is a priority in osteoarthritis research. MSCs are a heterogeneous
cell population with immunomodulatory and anti-inflammatory
properties. We have identified a novel biomarker (CD317) that allows
the isolation of MSCs subpopulations with tissue regenerative properties
(Y201, CD317-) and non-differentiating MSCs with an enriched proinflammatory
transcriptional profile (Y202, CD317þ) that make up an
average of 9% of the total MSCs population. We investigated the
immunomodulatory function of these subpopulations to understand
their role in disease processes and potential impact on regenerative
therapies.

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