The York Research Database

Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Chemical Tool

Miller, D. C., Reuillon, T., Molyneux, L., Blackburn, T. J., Cook, S., Edwards, N., Endicott, J. A., Golding, B. T., Griffin, R. J., Hardcastle, I. R., Heptinstall, A. B., Lochhead, P., Martin, M. P., Martin, N., Myers, S. M., Newell, D. R., Noble, R., Rigoreau, L. J. M., Thomas, H., Tucker, J. A. & 6 others, Wang, L-Z., Waring, M. J., Wong, A-C., Wedge, S., Noble, M. & Cano, C., 25 Apr 2022, (E-pub ahead of print)

Article in JOURNAL OF MEDICINAL CHEMISTRY

Recent Advances in Kinase Drug Discovery Part I: the Editors’ Take

Tucker, J. A. & Martin, M. P., 15 Jul 2021

Editorial in International Journal of Molecular Sciences

An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)

Al-Khawaldeh, I., Alyassiri, M., Aldred, G., Basmadjian, C., Bordoni, C., Harnor, S. J., Heptinstall, A. B., Hobson, S., Jennings, C., Khalifa, S., Lebraud, H., Martin, M. P., Miller, D. C., Shrives, H., De Souza, J., Stewart, H., Temple, M. J., Thomas, H., Totobenazara, J., Tucker, J. A. & 12 others, Tudhope, S., Wang, L-Z., Bronowska, A., Cano, C., Endicott, J. A., Golding, B., Hardcastle, I. R., Hickson, I., Wedge, S., Willmore, E., Noble, M. E. M. & Waring, M. J., 2 Jul 2021, (E-pub ahead of print)

Article in JOURNAL OF MEDICINAL CHEMISTRY

The thrombopoietin receptor: revisiting the master regulator of platelet production

Hitchcock, I. S., Hafer, M., Sangkhae, V. & Tucker, J. A., 7 Jun 2021, (E-pub ahead of print)

Article in Platelets

Validation of IMS-MS as a screening tool to identify type II kinase inhibitors of FGFR1 kinase

Beeston, H., Klein, T., Norman, R., Tucker, J. A., Anderson, M., Ashcroft, A. E. & Holdgate, G., 26 May 2021, (E-pub ahead of print)

Article in Rapid Communications in Mass Spectrometry

Parallel Optimisation of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Chemical Tool

Miller, D. C., Reuillon, T., Molyneux, L., Blackburn, T. J., Cook, S., Edwards, N., Endicott, J. A., Golding, B. T., Griffin, R. J., Hardcastle, I. R., Heptinstall, A. B., Lochhead, P., Martin, M. P., Martin, N., Myers, S. M., Newell, D. R., Noble, R., Rigoreau, L. J. M., Thomas, H., Tucker, J. A. & 6 others, Wang, L-Z., Waring, M. J., Wong, A-C., Wedge, S., Noble, M. & Cano, C., 25 Apr 2022, (E-pub ahead of print)

Article in JOURNAL OF MEDICINAL CHEMISTRY

Expansion of the 4-(Diethylamino)benzaldehyde Scaffold to Explore the Impact on Aldehyde Dehydrogenase Activity and Antiproliferative Activity in Prostate Cancer

Ibrahim, A. I. M., Batlle, E., Sneha, S., Jiménez, R., Pequerul, R., Parés, X., Rüngeler, T., Jha, V., Tuccinardi, T., Sadiq, M., Frame, F., Maitland, N. J., Farrés, J. & Pors, K., 10 Mar 2022

Article in JOURNAL OF MEDICINAL CHEMISTRY

An alkynylpyrimidine-based covalent inhibitor that targets a unique cysteine in NF-κB-inducing kinase (NIK)

Al-Khawaldeh, I., Alyassiri, M., Aldred, G., Basmadjian, C., Bordoni, C., Harnor, S. J., Heptinstall, A. B., Hobson, S., Jennings, C., Khalifa, S., Lebraud, H., Martin, M. P., Miller, D. C., Shrives, H., De Souza, J., Stewart, H., Temple, M. J., Thomas, H., Totobenazara, J., Tucker, J. A. & 12 others, Tudhope, S., Wang, L-Z., Bronowska, A., Cano, C., Endicott, J. A., Golding, B., Hardcastle, I. R., Hickson, I., Wedge, S., Willmore, E., Noble, M. E. M. & Waring, M. J., 2 Jul 2021, (E-pub ahead of print)

Article in JOURNAL OF MEDICINAL CHEMISTRY

Novel Thienopyrimidine Inhibitors of Leishmania N-Myristoyltransferase with On-Target Activity in Intracellular Amastigotes

Bell, A. S., Yu, Z., Hutton, J. A., Wright, M. H., Brannigan, J. A., Paape, D., Roberts, S. M., Sutherell, C. L., Ritzefeld, M., Wilkinson, A. J., Smith, D. F., Leatherbarrow, R. J. & Tate, E. W., 23 Jul 2020

Article in JOURNAL OF MEDICINAL CHEMISTRY