Abstract
Flexible, strong scaffolds were created by crosslinking PCL with 1,6-hexamethylenediisocyanate, using paraffin beads as a porogen. Particulate leaching generated homogeneous scaffolds with interconnected spherical pores of 5-200¿µm. Subcutaneous implantation in rats for 3 months resulted in minimal scaffold resorption and a non-inflammatory regenerative host response, with complete infiltration by alternatively-activated CD68(+) macrophages. In addition, scaffolds were populated extensively along microfractures by a stromal matrix, which was highly vascularised and contained a subset of stromal cells that expressed the anti-inflammatory CD163 antigen. Such microfractures may be an important physical feature for directing stromal integration and vascularisation events.
| Original language | English |
|---|---|
| Pages (from-to) | 618-27 |
| Number of pages | 10 |
| Journal | Macromolecular bioscience |
| Volume | 11 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 12 May 2011 |