Cellular integration and vascularisation promoted by a resorbable, particulate-leached, cross-linked poly(e-caprolactone) scaffold

Simon C Baker, Geraldine Rohman, Jennifer Hinley, Jens Stahlschmidt, Neil R Cameron, Jennifer Southgate

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Flexible, strong scaffolds were created by crosslinking PCL with 1,6-hexamethylenediisocyanate, using paraffin beads as a porogen. Particulate leaching generated homogeneous scaffolds with interconnected spherical pores of 5-200¿µm. Subcutaneous implantation in rats for 3 months resulted in minimal scaffold resorption and a non-inflammatory regenerative host response, with complete infiltration by alternatively-activated CD68(+) macrophages. In addition, scaffolds were populated extensively along microfractures by a stromal matrix, which was highly vascularised and contained a subset of stromal cells that expressed the anti-inflammatory CD163 antigen. Such microfractures may be an important physical feature for directing stromal integration and vascularisation events.
Original languageEnglish
Pages (from-to)618-27
Number of pages10
JournalMacromolecular bioscience
Issue number5
Publication statusPublished - 12 May 2011

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