Chains of superparamagnetic nanoparticles as biomedical sensing and diagnostic tools

Research output: Contribution to conferencePaper

Author(s)

Department/unit(s)

Conference

ConferenceInternational Symposium on New Frontiers in Fiber Materials Science 2011
CountryUnited States
CityCharleston
Conference date(s)11/10/1113/10/11

Publication details

DatePublished - 1 Jan 2011
Original languageEnglish

Abstract

MOTIVATION AND SUMMARY: Magnetic nanoparticles are being widely employed for separation and detection of various biological targets including bacteria, mammalian cells, viruses and molecules. The advantage of magnetic detection over fluorescence based methods is the absence of scattering, screening or interference for magnetic fields in typical biological media. However, fluorescence based detection does have one important advantage: it offers the possibility of multiplexing (detecting multiple targets in parallel), which has not been implemented with magnetic based assays. Here we propose that chains of magnetic nanoparticles could be fabricated to have different rates of their magnetization relaxation (so-called Neel relaxation) and that different magnetic relaxation rates could be used to distinguish different chains and, therefore, enable their use in detection and separation of multiple biological targets in parallel. We report on the initial modeling result of Neel relaxation in magnetic nanoparticle chains.

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