By the same authors

From the same journal

From the same journal

Challenges in the development of bio-based solvents: A case study on methyl(2,2-dimethyl-1,3-dioxolan-4-yl)methyl carbonate as an alternative aprotic solvent

Research output: Contribution to journalArticlepeer-review

Full text download(s)

Published copy (DOI)



Publication details

DateAccepted/In press - 17 Feb 2017
DateE-pub ahead of print - 13 Mar 2017
DatePublished (current) - 1 Sep 2017
Number of pages17
Pages (from-to)157-173
Early online date13/03/17
Original languageEnglish


Many traditional solvents have drawbacks including sustainability and toxicity issues. Legislations such as REACH is driving the move towards less hazardous chemicals and production processes. Therefore, safer bio-based solvents need to be developed. Herein, a 10 step method has been proposed for the development of new bio-based solvents that utilise a combination of in silico modelling of Hansen solubility parameters (HSPs), experimental Kamlet-Abboud-Taft parameters, selection of green synthetic routes followed by applications testing and toxicity measurements. The challenges that the chemical industry face in the development of new bio-based solvents are highlighted through a case study on methyl (2,2-dimethyl-1,3-dioxolan-4-yl) methyl carbonate (MMC) which can be synthesised from glycerol. Although MMC is an attractive candidate as a replacement solvent, simply being bio-derived is not enough for a molecule to be regarded as green. The methodology of solvent development described here is a broadly applicable protocol that will indicate if a new bio-based solvent is functionally proficient, but will also highlight the importance of early stage Kamlet-Abboud-Taft parameters determination and toxicity testing in the development of a green solvent.

Bibliographical note

© Royal Society of Chemistry 2017. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations