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Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging 

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Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging . / De Luca, Elena; Harvey, Peter; Chalmers, Kirsten H.; Mishra, Anurag; Senanayake, P. Kanthi; Wilson, J. Ian; Botta, Mauro; Fekete, Marianna; Blamire, Andrew M.; Parker, David.

In: Journal of Biological Inorganic Chemistry, Vol. 19, No. 2, 02.2014, p. 215-227.

Research output: Contribution to journalArticlepeer-review

Harvard

De Luca, E, Harvey, P, Chalmers, KH, Mishra, A, Senanayake, PK, Wilson, JI, Botta, M, Fekete, M, Blamire, AM & Parker, D 2014, 'Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging ', Journal of Biological Inorganic Chemistry, vol. 19, no. 2, pp. 215-227. https://doi.org/10.1007/s00775-013-1028-y

APA

De Luca, E., Harvey, P., Chalmers, K. H., Mishra, A., Senanayake, P. K., Wilson, J. I., Botta, M., Fekete, M., Blamire, A. M., & Parker, D. (2014). Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging . Journal of Biological Inorganic Chemistry, 19(2), 215-227. https://doi.org/10.1007/s00775-013-1028-y

Vancouver

De Luca E, Harvey P, Chalmers KH, Mishra A, Senanayake PK, Wilson JI et al. Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging . Journal of Biological Inorganic Chemistry. 2014 Feb;19(2):215-227. https://doi.org/10.1007/s00775-013-1028-y

Author

De Luca, Elena ; Harvey, Peter ; Chalmers, Kirsten H. ; Mishra, Anurag ; Senanayake, P. Kanthi ; Wilson, J. Ian ; Botta, Mauro ; Fekete, Marianna ; Blamire, Andrew M. ; Parker, David. / Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging . In: Journal of Biological Inorganic Chemistry. 2014 ; Vol. 19, No. 2. pp. 215-227.

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@article{877b889d9ebd46a4bcddf29d2f9b6c0b,
title = "Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging ",
abstract = "Medium molecular weight glycol chitosan conjugates have been prepared, linked by an amide bond to paramagnetic Gd(III), Ho(III) and Dy(III) macrocyclic complexes in which a trifluoromethyl reporter group is located 6.5 {\AA} from the paramagnetic centre. The faster relaxation of the observed nucleus allows modified pulse sequences to be used with shorter acquisition times. The polydisperse materials have been characterised by gel permeation chromatography, revealing an average molecular weight on the order of 13,800 (Gd), 14,600 (Dy) and 16,200 (Ho), consistent with the presence of 8.5, 9.5 and 13 complexes, respectively. The gadolinium conjugate was prepared for both a q = 1 monoamide tricarboxylate conjugate (r 1p 11.2 mM-1 s-1, 310 K, 1.4 T) and a q = 0 triphosphinate system, and conventional contrast-enhanced proton MRI studies at 7 T were undertaken in mice bearing an HT-29 or an HCT-116 colorectal tumour xenograft (17 μmol/kg). Enhanced contrast was observed following injection in the tail vein in tumour tissue, with uptake also evident in the liver and kidney with a tumour-to-liver ratio of 2:1 at 13 min, and large amounts in the kidney and bladder consistent with predominant renal clearance. Parallel experiments observing the 19F resonance in the holmium conjugate complex using a surface coil did not succeed owing to its high R 2 value (750 Hz, 7 T). However, the fluorine signal in the dysprosium triphosphinate chitosan conjugate [R 1/R 2 = 0.6 and R 1 = 145 Hz (7 T)] was sharper and could be observed in vivo at -65.7 ppm, following intravenous tail vein injection of a dose of 34 μmol/kg.",
keywords = "Contrast agents, Fluorine, Imaging, MRI, Tumour uptake",
author = "{De Luca}, Elena and Peter Harvey and Chalmers, {Kirsten H.} and Anurag Mishra and Senanayake, {P. Kanthi} and Wilson, {J. Ian} and Mauro Botta and Marianna Fekete and Blamire, {Andrew M.} and David Parker",
year = "2014",
month = feb,
doi = "10.1007/s00775-013-1028-y",
language = "English",
volume = "19",
pages = "215--227",
journal = "Journal of Biological Inorganic Chemistry",
issn = "0949-8257",
publisher = "Springer Verlag",
number = "2",

}

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TY - JOUR

T1 - Characterisation and evaluation of paramagnetic fluorine labelled glycol chitosan conjugates for 19F and 1H magnetic resonance imaging 

AU - De Luca, Elena

AU - Harvey, Peter

AU - Chalmers, Kirsten H.

AU - Mishra, Anurag

AU - Senanayake, P. Kanthi

AU - Wilson, J. Ian

AU - Botta, Mauro

AU - Fekete, Marianna

AU - Blamire, Andrew M.

AU - Parker, David

PY - 2014/2

Y1 - 2014/2

N2 - Medium molecular weight glycol chitosan conjugates have been prepared, linked by an amide bond to paramagnetic Gd(III), Ho(III) and Dy(III) macrocyclic complexes in which a trifluoromethyl reporter group is located 6.5 Å from the paramagnetic centre. The faster relaxation of the observed nucleus allows modified pulse sequences to be used with shorter acquisition times. The polydisperse materials have been characterised by gel permeation chromatography, revealing an average molecular weight on the order of 13,800 (Gd), 14,600 (Dy) and 16,200 (Ho), consistent with the presence of 8.5, 9.5 and 13 complexes, respectively. The gadolinium conjugate was prepared for both a q = 1 monoamide tricarboxylate conjugate (r 1p 11.2 mM-1 s-1, 310 K, 1.4 T) and a q = 0 triphosphinate system, and conventional contrast-enhanced proton MRI studies at 7 T were undertaken in mice bearing an HT-29 or an HCT-116 colorectal tumour xenograft (17 μmol/kg). Enhanced contrast was observed following injection in the tail vein in tumour tissue, with uptake also evident in the liver and kidney with a tumour-to-liver ratio of 2:1 at 13 min, and large amounts in the kidney and bladder consistent with predominant renal clearance. Parallel experiments observing the 19F resonance in the holmium conjugate complex using a surface coil did not succeed owing to its high R 2 value (750 Hz, 7 T). However, the fluorine signal in the dysprosium triphosphinate chitosan conjugate [R 1/R 2 = 0.6 and R 1 = 145 Hz (7 T)] was sharper and could be observed in vivo at -65.7 ppm, following intravenous tail vein injection of a dose of 34 μmol/kg.

AB - Medium molecular weight glycol chitosan conjugates have been prepared, linked by an amide bond to paramagnetic Gd(III), Ho(III) and Dy(III) macrocyclic complexes in which a trifluoromethyl reporter group is located 6.5 Å from the paramagnetic centre. The faster relaxation of the observed nucleus allows modified pulse sequences to be used with shorter acquisition times. The polydisperse materials have been characterised by gel permeation chromatography, revealing an average molecular weight on the order of 13,800 (Gd), 14,600 (Dy) and 16,200 (Ho), consistent with the presence of 8.5, 9.5 and 13 complexes, respectively. The gadolinium conjugate was prepared for both a q = 1 monoamide tricarboxylate conjugate (r 1p 11.2 mM-1 s-1, 310 K, 1.4 T) and a q = 0 triphosphinate system, and conventional contrast-enhanced proton MRI studies at 7 T were undertaken in mice bearing an HT-29 or an HCT-116 colorectal tumour xenograft (17 μmol/kg). Enhanced contrast was observed following injection in the tail vein in tumour tissue, with uptake also evident in the liver and kidney with a tumour-to-liver ratio of 2:1 at 13 min, and large amounts in the kidney and bladder consistent with predominant renal clearance. Parallel experiments observing the 19F resonance in the holmium conjugate complex using a surface coil did not succeed owing to its high R 2 value (750 Hz, 7 T). However, the fluorine signal in the dysprosium triphosphinate chitosan conjugate [R 1/R 2 = 0.6 and R 1 = 145 Hz (7 T)] was sharper and could be observed in vivo at -65.7 ppm, following intravenous tail vein injection of a dose of 34 μmol/kg.

KW - Contrast agents

KW - Fluorine

KW - Imaging

KW - MRI

KW - Tumour uptake

UR - http://www.scopus.com/inward/record.url?scp=84893733160&partnerID=8YFLogxK

U2 - 10.1007/s00775-013-1028-y

DO - 10.1007/s00775-013-1028-y

M3 - Article

C2 - 23955558

AN - SCOPUS:84893733160

VL - 19

SP - 215

EP - 227

JO - Journal of Biological Inorganic Chemistry

JF - Journal of Biological Inorganic Chemistry

SN - 0949-8257

IS - 2

ER -