Characterising neurological time series data using biologically motivated networks of coupled discrete maps

TY - JOUR

T1 - Characterising neurological time series data using biologically motivated networks of coupled discrete maps

AU - Lones, Michael A

AU - Smith, Stephen L

AU - Tyrrell, Andy M

AU - Alty, Jane E

AU - Jamieson, D R Stuart

N1 - Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

PY - 2013/5

Y1 - 2013/5

N2 - Artificial biochemical networks (ABNs) are a class of computational dynamical system whose architectures are motivated by the organisation of genetic and metabolic networks in biological cells. Using evolutionary algorithms to search for networks with diagnostic potential, we demonstrate how ABNs can be used to carry out classification when stimulated with time series data collected from human subjects with and without Parkinson's disease. Artificial metabolic networks, composed of coupled discrete maps, offer the best recognition of Parkinsonian behaviour, achieving accuracies in the region of 90%. This is comparable to the diagnostic accuracies found in clinical diagnosis, and is significantly higher than those found in primary and non-expert secondary care. We also illustrate how an evolved classifier is able to recognise diverse features of Parkinsonian behaviour and, using perturbation analysis, show that the evolved classifiers have interesting computational behaviours.

AB - Artificial biochemical networks (ABNs) are a class of computational dynamical system whose architectures are motivated by the organisation of genetic and metabolic networks in biological cells. Using evolutionary algorithms to search for networks with diagnostic potential, we demonstrate how ABNs can be used to carry out classification when stimulated with time series data collected from human subjects with and without Parkinson's disease. Artificial metabolic networks, composed of coupled discrete maps, offer the best recognition of Parkinsonian behaviour, achieving accuracies in the region of 90%. This is comparable to the diagnostic accuracies found in clinical diagnosis, and is significantly higher than those found in primary and non-expert secondary care. We also illustrate how an evolved classifier is able to recognise diverse features of Parkinsonian behaviour and, using perturbation analysis, show that the evolved classifiers have interesting computational behaviours.

KW - Algorithms

KW - Computational Biology

KW - Humans

KW - Metabolic Networks and Pathways

KW - Models, Neurological

KW - Neural Networks (Computer)

KW - Parkinson Disease

KW - Reproducibility of Results

KW - Sensitivity and Specificity

UR - http://www.scopus.com/inward/record.url?scp=84875060235&partnerID=8YFLogxK

U2 - 10.1016/j.biosystems.2013.03.009

DO - 10.1016/j.biosystems.2013.03.009

M3 - Article

C2 - 23499822

SN - 0303-2647

VL - 112

SP - 94

EP - 101

JO - Biosystems

JF - Biosystems

IS - 2

ER -