Characterization of Host-Guest Complexes of Supramolecular Self-Assembled Cages Using EPR Spectroscopy

James D. Nicholas; Victor Chechik

doi:10.1021/acs.jpcb.0c02599

Characterization of Host-Guest Complexes of Supramolecular Self-Assembled Cages Using EPR Spectroscopy

James D. Nicholas, Victor Chechik

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

Host-guest interactions between nitroxide stable radicals and supramolecular coordination cages were investigated using electron paramagnetic resonance (EPR) spectroscopy in water and acetonitrile. TEMPO showed negligible association with the cages in water, while 4-oxo-TEMPO bound with a strength comparable to that previously reported for related ketones. Carboxylic acid-functionalized nitroxides bound strongly to the acetonitrile-soluble coordination cages. In all cases, host-guest complex formation resulted in significant decreases in the molecular tumbling rate of the guests, with tumbling becoming strongly anisotropic. The polarity of the cage environment in both solvents was found to be intermediate between water and acetonitrile.

Original language	English
Pages (from-to)	5646-5653
Number of pages	8
Journal	Journal of Physical Chemistry B
Volume	124
Issue number	27
Early online date	10 Jun 2020
DOIs	https://doi.org/10.1021/acs.jpcb.0c02599
Publication status	Published - 10 Jul 2020

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© 2020 American Chemical Society. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details.

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Characterization of Host-Guest Complexes of Supramolecular Self-Assembled Cages Using EPR Spectroscopy

Abstract

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