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Chemical and Biological Aspects of Nutritional Immunity - Perspectives for New Anti-infectives Targeting Iron Uptake Systems: Perspectives for New Anti-infectives Targeting Iron Uptake Systems

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JournalAngewandte Chemie International Edition
DateAccepted/In press - 25 Apr 2017
DateE-pub ahead of print - 25 Apr 2017
DatePublished (current) - 13 Oct 2017
Volume56
Number of pages24
Pages (from-to)2-25
Early online date25/04/17
Original languageEnglish

Abstract

Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.

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© Wiley, 2017. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

    Research areas

  • Antibiotics, Heme proteins, Iron, Nutritional immunity, Siderophores

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