Research output: Contribution to journal › Review article › peer-review
2.58 MB, PDF document
Journal | Angewandte Chemie International Edition |
---|---|
Date | Accepted/In press - 25 Apr 2017 |
Date | E-pub ahead of print - 25 Apr 2017 |
Date | Published (current) - 13 Oct 2017 |
Volume | 56 |
Number of pages | 24 |
Pages (from-to) | 2-25 |
Early online date | 25/04/17 |
Original language | English |
Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.
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Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Research output: Contribution to journal › Article › peer-review
Activity: Talk or presentation › Invited talk
Project: Research project (funded) › Research
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