Chemical and Biological Aspects of Nutritional Immunity - Perspectives for New Anti-infectives Targeting Iron Uptake Systems: Perspectives for New Anti-infectives Targeting Iron Uptake Systems

Ursula Bilitewski*, Joshua A.V. Blodgett, Anne Kathrin Duhme-Klair, Sabrina Dallavalle, Sabine Laschat, Anne Routledge, Rainer Schobert

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.

Original languageEnglish
Pages (from-to)2-25
Number of pages24
JournalAngewandte Chemie International Edition
Early online date25 Apr 2017
Publication statusPublished - 13 Oct 2017

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© Wiley, 2017. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details


  • Antibiotics
  • Heme proteins
  • Iron
  • Nutritional immunity
  • Siderophores

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