Chemical and Biological Aspects of Nutritional Immunity - Perspectives for New Anti-infectives Targeting Iron Uptake Systems: Perspectives for New Anti-infectives Targeting Iron Uptake Systems

TY - JOUR

T1 - Chemical and Biological Aspects of Nutritional Immunity - Perspectives for New Anti-infectives Targeting Iron Uptake Systems

T2 - Perspectives for New Anti-infectives Targeting Iron Uptake Systems

AU - Bilitewski, Ursula

AU - Blodgett, Joshua A.V.

AU - Duhme-Klair, Anne Kathrin

AU - Dallavalle, Sabrina

AU - Laschat, Sabine

AU - Routledge, Anne

AU - Schobert, Rainer

N1 - © Wiley, 2017. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2017/10/13

Y1 - 2017/10/13

N2 - Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.

AB - Upon bacterial infection, one of the defense mechanisms of the host is the withdrawal of essential metal ions, in particular iron, which leads to "nutritional immunity". However, bacteria have evolved strategies to overcome iron starvation, for example, by stealing iron from the host or other bacteria through specific iron chelators with high binding affinity. Fortunately, these complex interactions between the host and pathogen that lead to metal homeostasis provide several opportunities for interception and, thus, allow the development of novel antibacterial compounds. This Review focuses on iron, discusses recent highlights, and gives some future perspectives which are relevant in the fight against antibiotic resistance.

KW - Antibiotics

KW - Heme proteins

KW - Iron

KW - Nutritional immunity

KW - Siderophores

UR - http://www.scopus.com/inward/record.url?scp=85031316646&partnerID=8YFLogxK

U2 - 10.1002/anie.201701586

DO - 10.1002/anie.201701586

M3 - Review article

C2 - 28439959

SN - 1433-7851

VL - 56

SP - 2

EP - 25

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

ER -