The York Research Database

Rapid “high” temperature batch and flow lithiation-trapping of N-Boc pyrrolidine

Kwong, A., Firth, J. D., Farmer, T. J. & O'Brien, P., 12 Feb 2021

Article in Tetrahedron

Fragment-derived modulators of an industrial β-glucosidase

Makraki, E., Darby, J. F., Carneiro, M. G., Firth, J. D., Heyam, A., Ab, E., O'Brien, P., Siegal, G. & Hubbard, R. E., 26 Nov 2020

Article in The Biochemical journal

Crystallographic and electrophilic fragment screening of the SARS-CoV-2 main protease

Douangamath, A., Fearon, D., Gehrtz, P., Krojer, T., Lukacik, P., Owen, C. D., Resnick, E., Strain-Damerell, C., Aimon, A., Ábrányi-Balogh, P., Brandão-Neto, J., Carbery, A., Davison, G., Dias, A., Downes, T. D., Dunnett, L., Fairhead, M., Firth, J. D., Jones, S. P., Keeley, A. & 14 others, Keserü, G. M., Klein, H. F., Martin, M. P., Noble, M. E. M., O’Brien, P., Powell, A., Reddi, R. N., Skyner, R., Snee, M., Waring, M. J., Wild, C., London, N., von Delft, F. & Walsh, M. A., 7 Oct 2020

Article in Nature Communications

Design and Synthesis of 56 Shape Diverse 3-D Fragments

O'Brien, P., Downes, T. D., Jones, S. P., Klein, H. F., Wheldon, M. C., Atobe, M., Bond, P. S., Firth, J. D., Chan, N. S., Waddelove, L., Hubbard, R. E., Blakemore, D. C., De Fusco, C., Roughley, S. D., Vidler, L. R., Whatton, M. A., Woolford, A. J-A. & Wrigley, G. L., 21 Apr 2020

Article in Chemistry : A European Journal

A synthetic and spectroscopic investigation of the asymmetric α-lithiation-trapping of six-membered N-Boc heterocycles using Alexakis diamines

Firth, J., Gelardi, G., Rayner, P. J., Stead, D. & O'Brien, P. A., 20 Jun 2018

Article in Heterocycles