Chemokines on the move: control by the chemokine "interceptors" Duffy blood group antigen and D6

Robert Nibbs; Gerard Graham; Antal Rot

doi:10.1016/j.smim.2003.08.006

Chemokines on the move: control by the chemokine "interceptors" Duffy blood group antigen and D6

Robert Nibbs, Gerard Graham, Antal Rot

Research output: Contribution to journal › Article › peer-review

Abstract

Chemokines drive and direct leukocyte trafficking across the biological barriers. Controlling the microanatomical localization and quantity of chemokines is of fundamental importance in regulating these migratory responses. Here we discuss the emerging roles that two atypical chemokine receptors, Duffy antigen and D6, may play in controlling chemokine movement and how this may impinge on chemokine function. Mechanistically, Duffy antigen and D6 represent a subclass of chemokine internalizing receptors, "interceptors," taking chemokines into nucleated cells in the apparent absence of signaling. The subsequent fate of chemokines, either transport or degradation, may ultimately depend on cell type-specific targeting within the endocytotic pathway.

Original language	English
Pages (from-to)	287-94
Number of pages	8
Journal	Seminars in immunology
Volume	15
Issue number	5
DOIs	https://doi.org/10.1016/j.smim.2003.08.006
Publication status	Published - Oct 2003

Keywords

Animals
Chemokines
Duffy Blood-Group System
Endothelial Cells
Erythrocytes
Humans
Protein Transport
Receptors, CCR10
Receptors, Chemokine

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10.1016/j.smim.2003.08.006

Cite this

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title = "Chemokines on the move: control by the chemokine {"}interceptors{"} Duffy blood group antigen and D6",

abstract = "Chemokines drive and direct leukocyte trafficking across the biological barriers. Controlling the microanatomical localization and quantity of chemokines is of fundamental importance in regulating these migratory responses. Here we discuss the emerging roles that two atypical chemokine receptors, Duffy antigen and D6, may play in controlling chemokine movement and how this may impinge on chemokine function. Mechanistically, Duffy antigen and D6 represent a subclass of chemokine internalizing receptors, {"}interceptors,{"} taking chemokines into nucleated cells in the apparent absence of signaling. The subsequent fate of chemokines, either transport or degradation, may ultimately depend on cell type-specific targeting within the endocytotic pathway.",

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author = "Robert Nibbs and Gerard Graham and Antal Rot",

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AU - Graham, Gerard

AU - Rot, Antal

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N2 - Chemokines drive and direct leukocyte trafficking across the biological barriers. Controlling the microanatomical localization and quantity of chemokines is of fundamental importance in regulating these migratory responses. Here we discuss the emerging roles that two atypical chemokine receptors, Duffy antigen and D6, may play in controlling chemokine movement and how this may impinge on chemokine function. Mechanistically, Duffy antigen and D6 represent a subclass of chemokine internalizing receptors, "interceptors," taking chemokines into nucleated cells in the apparent absence of signaling. The subsequent fate of chemokines, either transport or degradation, may ultimately depend on cell type-specific targeting within the endocytotic pathway.

AB - Chemokines drive and direct leukocyte trafficking across the biological barriers. Controlling the microanatomical localization and quantity of chemokines is of fundamental importance in regulating these migratory responses. Here we discuss the emerging roles that two atypical chemokine receptors, Duffy antigen and D6, may play in controlling chemokine movement and how this may impinge on chemokine function. Mechanistically, Duffy antigen and D6 represent a subclass of chemokine internalizing receptors, "interceptors," taking chemokines into nucleated cells in the apparent absence of signaling. The subsequent fate of chemokines, either transport or degradation, may ultimately depend on cell type-specific targeting within the endocytotic pathway.

KW - Animals

KW - Chemokines

KW - Duffy Blood-Group System

KW - Endothelial Cells

KW - Erythrocytes

KW - Humans

KW - Protein Transport

KW - Receptors, CCR10

KW - Receptors, Chemokine

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DO - 10.1016/j.smim.2003.08.006

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SN - 1044-5323

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EP - 294

JO - Seminars in immunology

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