Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline

Edric Paw Cho Sing, Paula D. Robinson, Jacqueline Flank, Mark Holdsworth, Jennifer Thackray, Jason Freedman, Paul Gibson, Andrea D. Orsey, Priya Patel, Robert Phillips, Carol Portwine, Jennifer L. Raybin, Sandra Cabral, Lillian Sung, L. Lee Dupuis*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


This clinical practice guideline (CPG) provides clinicians with recommendations regarding chemotherapy emetogenicity classification in pediatric oncology patients. This information is critically important for the appropriate selection of antiemetic prophylaxis. Recommendations are based on a systematic review limited to pediatric patients and a framework for classification when antiemetic prophylaxis is provided. Findings of 87 publications informed the emetogenicity classification of 49 single-agent and 13 combination-agent regimens. Information required for the classification of many chemotherapies commonly administered to pediatric patients is lacking. In the absence of pediatric data, consultation of methodologically sound CPGs aimed at adult oncology patients may be appropriate.

Original languageEnglish
Article numbere27646
JournalPediatric Blood and Cancer
Early online date7 Feb 2019
Publication statusE-pub ahead of print - 7 Feb 2019


  • chemotherapy
  • chemotherapy-induced nausea and vomiting
  • emetogenicity
  • pediatric
  • supportive care
  • vomiting

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