Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline

Edric Paw Cho Sing; Paula D. Robinson; Jacqueline Flank; Mark Holdsworth; Jennifer Thackray; Jason Freedman; Paul Gibson; Andrea D. Orsey; Priya Patel; Robert Phillips; Carol Portwine; Jennifer L. Raybin; Sandra Cabral; Lillian Sung; L. Lee Dupuis

doi:10.1002/pbc.27646

Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline

Edric Paw Cho Sing, Paula D. Robinson, Jacqueline Flank, Mark Holdsworth, Jennifer Thackray, Jason Freedman, Paul Gibson, Andrea D. Orsey, Priya Patel, Robert Phillips, Carol Portwine, Jennifer L. Raybin, Sandra Cabral, Lillian Sung, L. Lee Dupuis^*

^*Corresponding author for this work

Centre for Reviews and Dissemination

Research output: Contribution to journal › Review article › peer-review

Abstract

This clinical practice guideline (CPG) provides clinicians with recommendations regarding chemotherapy emetogenicity classification in pediatric oncology patients. This information is critically important for the appropriate selection of antiemetic prophylaxis. Recommendations are based on a systematic review limited to pediatric patients and a framework for classification when antiemetic prophylaxis is provided. Findings of 87 publications informed the emetogenicity classification of 49 single-agent and 13 combination-agent regimens. Information required for the classification of many chemotherapies commonly administered to pediatric patients is lacking. In the absence of pediatric data, consultation of methodologically sound CPGs aimed at adult oncology patients may be appropriate.

Original language	English
Article number	e27646
Journal	Pediatric Blood and Cancer
Early online date	7 Feb 2019
DOIs	https://doi.org/10.1002/pbc.27646
Publication status	E-pub ahead of print - 7 Feb 2019

Keywords

chemotherapy
chemotherapy-induced nausea and vomiting
emetogenicity
pediatric
supportive care
vomiting

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10.1002/pbc.27646

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Paw Cho Sing, E., Robinson, P. D., Flank, J., Holdsworth, M., Thackray, J., Freedman, J., Gibson, P., Orsey, A. D., Patel, P., Phillips, R., Portwine, C., Raybin, J. L., Cabral, S., Sung, L., & Dupuis, L. L. (2019). Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline. Pediatric Blood and Cancer, Article e27646. Advance online publication. https://doi.org/10.1002/pbc.27646

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title = "Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline",

abstract = "This clinical practice guideline (CPG) provides clinicians with recommendations regarding chemotherapy emetogenicity classification in pediatric oncology patients. This information is critically important for the appropriate selection of antiemetic prophylaxis. Recommendations are based on a systematic review limited to pediatric patients and a framework for classification when antiemetic prophylaxis is provided. Findings of 87 publications informed the emetogenicity classification of 49 single-agent and 13 combination-agent regimens. Information required for the classification of many chemotherapies commonly administered to pediatric patients is lacking. In the absence of pediatric data, consultation of methodologically sound CPGs aimed at adult oncology patients may be appropriate.",

keywords = "chemotherapy, chemotherapy-induced nausea and vomiting, emetogenicity, pediatric, supportive care, vomiting",

author = "{Paw Cho Sing}, Edric and Robinson, {Paula D.} and Jacqueline Flank and Mark Holdsworth and Jennifer Thackray and Jason Freedman and Paul Gibson and Orsey, {Andrea D.} and Priya Patel and Robert Phillips and Carol Portwine and Raybin, {Jennifer L.} and Sandra Cabral and Lillian Sung and Dupuis, {L. Lee}",

year = "2019",

month = feb,

day = "7",

doi = "10.1002/pbc.27646",

language = "English",

journal = "Pediatric Blood and Cancer",

issn = "1545-5009",

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AU - Paw Cho Sing, Edric

AU - Robinson, Paula D.

AU - Flank, Jacqueline

AU - Holdsworth, Mark

AU - Thackray, Jennifer

AU - Freedman, Jason

AU - Gibson, Paul

AU - Orsey, Andrea D.

AU - Patel, Priya

AU - Phillips, Robert

AU - Portwine, Carol

AU - Raybin, Jennifer L.

AU - Cabral, Sandra

AU - Sung, Lillian

AU - Dupuis, L. Lee

PY - 2019/2/7

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AB - This clinical practice guideline (CPG) provides clinicians with recommendations regarding chemotherapy emetogenicity classification in pediatric oncology patients. This information is critically important for the appropriate selection of antiemetic prophylaxis. Recommendations are based on a systematic review limited to pediatric patients and a framework for classification when antiemetic prophylaxis is provided. Findings of 87 publications informed the emetogenicity classification of 49 single-agent and 13 combination-agent regimens. Information required for the classification of many chemotherapies commonly administered to pediatric patients is lacking. In the absence of pediatric data, consultation of methodologically sound CPGs aimed at adult oncology patients may be appropriate.

KW - chemotherapy

KW - chemotherapy-induced nausea and vomiting

KW - emetogenicity

KW - pediatric

KW - supportive care

KW - vomiting

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DO - 10.1002/pbc.27646

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SN - 1545-5009

JO - Pediatric Blood and Cancer

JF - Pediatric Blood and Cancer

M1 - e27646

ER -

Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline

Abstract

Keywords

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Round 8

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Classification of the acute emetogenicity of chemotherapy in pediatric patients: A clinical practice guideline

Abstract

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Round 8

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