Classification of treatment-related mortality in children with cancer: a systematic assessment

Sarah Alexander; Jason D Pole; Paul Gibson; Michelle Lee; Tanya Hesser; Susan N Chi; Christopher C Dvorak; Brian Fisher; Henrik Hasle; Jukka Kanerva; Anja Möricke; Bob Phillips; Elizabeth Raetz; Carlos Rodriguez-Galindo; Sujith Samarasinghe; Kjeld Schmiegelow; Wim Tissing; Thomas Lehrnbecher; Lillian Sung; International Pediatric Oncology Mortality Classification Group

doi:10.1016/S1470-2045(15)00197-7

Classification of treatment-related mortality in children with cancer: a systematic assessment

Sarah Alexander, Jason D Pole, Paul Gibson, Michelle Lee, Tanya Hesser, Susan N Chi, Christopher C Dvorak, Brian Fisher, Henrik Hasle, Jukka Kanerva, Anja Möricke, Bob Phillips, Elizabeth Raetz, Carlos Rodriguez-Galindo, Sujith Samarasinghe, Kjeld Schmiegelow, Wim Tissing, Thomas Lehrnbecher, Lillian Sung, International Pediatric Oncology Mortality Classification Group

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Abstract

Treatment-related mortality is an important outcome in paediatric cancer clinical trials. An international group of experts in supportive care in paediatric cancer developed a consensus-based definition of treatment-related mortality and a cause-of-death attribution system. The reliability and validity of the system was tested in 30 deaths, which were independently assessed by two clinical research associates and two paediatric oncologists. We defined treatment-related mortality as death occurring in the absence of progressive cancer. Of the 30 reviewed deaths, the reliability of classification for treatment-related mortality was noted as excellent by clinical research associates (κ=0·83, 95% CI 0·60-1·00) and paediatric oncologists (0·84, 0·63-1·00). Criterion validity was established because agreement between the consensus classifications by clinical research associates and paediatric oncologists was almost perfect (0·92, 0·78-1·00). Our approach should allow comparison of treatment-related mortality across trials and across time.

Original language	English
Pages (from-to)	e604-e610
Journal	Lancet oncology
Volume	16
Issue number	16
DOIs	https://doi.org/10.1016/S1470-2045(15)00197-7
Publication status	Published - Dec 2015

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10.1016/S1470-2045(15)00197-7

1 Research Group
1 Invited talk

Supportive care
Bob Phillips (Speaker)
15 Mar 2018
Activity: Talk or presentation › Invited talk
NCRI Teenage and Young Adult Clinical Studies Group (External organisation)
Bob Phillips (Advisor)
26 Jun 2017
Activity: Membership › Research Group

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Alexander, S., Pole, J. D., Gibson, P., Lee, M., Hesser, T., Chi, S. N., Dvorak, C. C., Fisher, B., Hasle, H., Kanerva, J., Möricke, A., Phillips, B., Raetz, E., Rodriguez-Galindo, C., Samarasinghe, S., Schmiegelow, K., Tissing, W., Lehrnbecher, T., Sung, L., & International Pediatric Oncology Mortality Classification Group (2015). Classification of treatment-related mortality in children with cancer: a systematic assessment. Lancet oncology, 16(16), e604-e610. https://doi.org/10.1016/S1470-2045(15)00197-7

@article{69f75451a93c418b81a090d056964049,

title = "Classification of treatment-related mortality in children with cancer: a systematic assessment",

abstract = "Treatment-related mortality is an important outcome in paediatric cancer clinical trials. An international group of experts in supportive care in paediatric cancer developed a consensus-based definition of treatment-related mortality and a cause-of-death attribution system. The reliability and validity of the system was tested in 30 deaths, which were independently assessed by two clinical research associates and two paediatric oncologists. We defined treatment-related mortality as death occurring in the absence of progressive cancer. Of the 30 reviewed deaths, the reliability of classification for treatment-related mortality was noted as excellent by clinical research associates (κ=0·83, 95% CI 0·60-1·00) and paediatric oncologists (0·84, 0·63-1·00). Criterion validity was established because agreement between the consensus classifications by clinical research associates and paediatric oncologists was almost perfect (0·92, 0·78-1·00). Our approach should allow comparison of treatment-related mortality across trials and across time.",

author = "Sarah Alexander and Pole, {Jason D} and Paul Gibson and Michelle Lee and Tanya Hesser and Chi, {Susan N} and Dvorak, {Christopher C} and Brian Fisher and Henrik Hasle and Jukka Kanerva and Anja M{\"o}ricke and Bob Phillips and Elizabeth Raetz and Carlos Rodriguez-Galindo and Sujith Samarasinghe and Kjeld Schmiegelow and Wim Tissing and Thomas Lehrnbecher and Lillian Sung and {International Pediatric Oncology Mortality Classification Group}",

year = "2015",

month = dec,

doi = "10.1016/S1470-2045(15)00197-7",

language = "English",

volume = "16",

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journal = "Lancet oncology",

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Alexander, S, Pole, JD, Gibson, P, Lee, M, Hesser, T, Chi, SN, Dvorak, CC, Fisher, B, Hasle, H, Kanerva, J, Möricke, A, Phillips, B, Raetz, E, Rodriguez-Galindo, C, Samarasinghe, S, Schmiegelow, K, Tissing, W, Lehrnbecher, T, Sung, L & International Pediatric Oncology Mortality Classification Group 2015, 'Classification of treatment-related mortality in children with cancer: a systematic assessment', Lancet oncology, vol. 16, no. 16, pp. e604-e610. https://doi.org/10.1016/S1470-2045(15)00197-7

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T1 - Classification of treatment-related mortality in children with cancer

T2 - a systematic assessment

AU - Alexander, Sarah

AU - Pole, Jason D

AU - Gibson, Paul

AU - Lee, Michelle

AU - Hesser, Tanya

AU - Chi, Susan N

AU - Dvorak, Christopher C

AU - Fisher, Brian

AU - Hasle, Henrik

AU - Kanerva, Jukka

AU - Möricke, Anja

AU - Phillips, Bob

AU - Raetz, Elizabeth

AU - Rodriguez-Galindo, Carlos

AU - Samarasinghe, Sujith

AU - Schmiegelow, Kjeld

AU - Tissing, Wim

AU - Lehrnbecher, Thomas

AU - Sung, Lillian

AU - International Pediatric Oncology Mortality Classification Group

PY - 2015/12

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N2 - Treatment-related mortality is an important outcome in paediatric cancer clinical trials. An international group of experts in supportive care in paediatric cancer developed a consensus-based definition of treatment-related mortality and a cause-of-death attribution system. The reliability and validity of the system was tested in 30 deaths, which were independently assessed by two clinical research associates and two paediatric oncologists. We defined treatment-related mortality as death occurring in the absence of progressive cancer. Of the 30 reviewed deaths, the reliability of classification for treatment-related mortality was noted as excellent by clinical research associates (κ=0·83, 95% CI 0·60-1·00) and paediatric oncologists (0·84, 0·63-1·00). Criterion validity was established because agreement between the consensus classifications by clinical research associates and paediatric oncologists was almost perfect (0·92, 0·78-1·00). Our approach should allow comparison of treatment-related mortality across trials and across time.

AB - Treatment-related mortality is an important outcome in paediatric cancer clinical trials. An international group of experts in supportive care in paediatric cancer developed a consensus-based definition of treatment-related mortality and a cause-of-death attribution system. The reliability and validity of the system was tested in 30 deaths, which were independently assessed by two clinical research associates and two paediatric oncologists. We defined treatment-related mortality as death occurring in the absence of progressive cancer. Of the 30 reviewed deaths, the reliability of classification for treatment-related mortality was noted as excellent by clinical research associates (κ=0·83, 95% CI 0·60-1·00) and paediatric oncologists (0·84, 0·63-1·00). Criterion validity was established because agreement between the consensus classifications by clinical research associates and paediatric oncologists was almost perfect (0·92, 0·78-1·00). Our approach should allow comparison of treatment-related mortality across trials and across time.

U2 - 10.1016/S1470-2045(15)00197-7

DO - 10.1016/S1470-2045(15)00197-7

M3 - Article

C2 - 26678213

SN - 1470-2045

VL - 16

SP - e604-e610

JO - Lancet oncology

JF - Lancet oncology

IS - 16

ER -

Classification of treatment-related mortality in children with cancer: a systematic assessment

Abstract

Bibliographical note

Access to Document

Activities

Supportive care

NCRI Teenage and Young Adult Clinical Studies Group (External organisation)

Cite this