Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil

Luana Aparecida Rogerio, Talita Yuri Takahashi, Luria Cardoso, Nayore Tamie Takamiya, Enaldo Vieira de Melo, Amelia Ribeiro de Jesus, Fabricia Alvisi de Oliveira, Sarah Forrester, Daniel C Jeffares, João Santana da Silva, José Marcos Ribeiro, Roque Pacheco Almeida, Sandra Regina Maruyama*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


We report a refractory and relapsed visceral leishmaniasis case in a child male patient followed from 2016 to 2020, whose clinical isolates from multiple relapses were analyzed at genome level. To the best of our knowledge, it is the first report that both visceral leishmaniasis and non-ulcerated cutaneous leishmaniasis have concomitantly manifested in the same patient. Importantly, sequence analysis revealed that the patient was co-infected with Leishmania infantum and a Crithidia-related parasite, which was previously found in a fatal case of visceral leishmaniasis from the same endemic region.

Original languageEnglish
Pages (from-to)85-88
Number of pages4
JournalInternational journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Publication statusPublished - 12 May 2023

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© 2023 The Authors.

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