Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil

Luana Aparecida Rogerio; Talita Yuri Takahashi; Luria Cardoso; Nayore Tamie Takamiya; Enaldo Vieira de Melo; Amelia Ribeiro de Jesus; Fabricia Alvisi de Oliveira; Sarah Forrester; Daniel C Jeffares; João Santana da Silva; José Marcos Ribeiro; Roque Pacheco Almeida; Sandra Regina Maruyama

doi:10.1016/j.ijid.2023.05.012

Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil

Luana Aparecida Rogerio, Talita Yuri Takahashi, Luria Cardoso, Nayore Tamie Takamiya, Enaldo Vieira de Melo, Amelia Ribeiro de Jesus, Fabricia Alvisi de Oliveira, Sarah Forrester, Daniel C Jeffares, João Santana da Silva, José Marcos Ribeiro, Roque Pacheco Almeida, Sandra Regina Maruyama^*

^*Corresponding author for this work

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

We report a refractory and relapsed visceral leishmaniasis case in a child male patient followed from 2016 to 2020, whose clinical isolates from multiple relapses were analyzed at genome level. To the best of our knowledge, it is the first report that both visceral leishmaniasis and non-ulcerated cutaneous leishmaniasis have concomitantly manifested in the same patient. Importantly, sequence analysis revealed that the patient was co-infected with Leishmania infantum and a Crithidia-related parasite, which was previously found in a fatal case of visceral leishmaniasis from the same endemic region.

Original language	English
Pages (from-to)	85-88
Number of pages	4
Journal	International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases
Volume	133
DOIs	https://doi.org/10.1016/j.ijid.2023.05.012
Publication status	Published - 12 May 2023

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Rogerio, L. A., Takahashi, T. Y., Cardoso, L., Takamiya, N. T., de Melo, E. V., de Jesus, A. R., de Oliveira, F. A., Forrester, S., Jeffares, D. C., da Silva, J. S., Ribeiro, J. M., Almeida, R. P., & Maruyama, S. R. (2023). Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, 133, 85-88. https://doi.org/10.1016/j.ijid.2023.05.012

Rogerio, Luana Aparecida ; Takahashi, Talita Yuri ; Cardoso, Luria et al. / Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil. In: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2023 ; Vol. 133. pp. 85-88.

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title = "Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil",

abstract = "We report a refractory and relapsed visceral leishmaniasis case in a child male patient followed from 2016 to 2020, whose clinical isolates from multiple relapses were analyzed at genome level. To the best of our knowledge, it is the first report that both visceral leishmaniasis and non-ulcerated cutaneous leishmaniasis have concomitantly manifested in the same patient. Importantly, sequence analysis revealed that the patient was co-infected with Leishmania infantum and a Crithidia-related parasite, which was previously found in a fatal case of visceral leishmaniasis from the same endemic region.",

author = "Rogerio, {Luana Aparecida} and Takahashi, {Talita Yuri} and Luria Cardoso and Takamiya, {Nayore Tamie} and {de Melo}, {Enaldo Vieira} and {de Jesus}, {Amelia Ribeiro} and {de Oliveira}, {Fabricia Alvisi} and Sarah Forrester and Jeffares, {Daniel C} and {da Silva}, {Jo{\~a}o Santana} and Ribeiro, {Jos{\'e} Marcos} and Almeida, {Roque Pacheco} and Maruyama, {Sandra Regina}",

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doi = "10.1016/j.ijid.2023.05.012",

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Rogerio, LA, Takahashi, TY, Cardoso, L, Takamiya, NT, de Melo, EV, de Jesus, AR, de Oliveira, FA, Forrester, S , Jeffares, DC, da Silva, JS, Ribeiro, JM, Almeida, RP & Maruyama, SR 2023, 'Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil', International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, vol. 133, pp. 85-88. https://doi.org/10.1016/j.ijid.2023.05.012

Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil. / Rogerio, Luana Aparecida; Takahashi, Talita Yuri; Cardoso, Luria et al.
In: International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases, Vol. 133, 12.05.2023, p. 85-88.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil

AU - Rogerio, Luana Aparecida

AU - Takahashi, Talita Yuri

AU - Cardoso, Luria

AU - Takamiya, Nayore Tamie

AU - de Melo, Enaldo Vieira

AU - de Jesus, Amelia Ribeiro

AU - de Oliveira, Fabricia Alvisi

AU - Forrester, Sarah

AU - Jeffares, Daniel C

AU - da Silva, João Santana

AU - Ribeiro, José Marcos

AU - Almeida, Roque Pacheco

AU - Maruyama, Sandra Regina

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Y1 - 2023/5/12

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AB - We report a refractory and relapsed visceral leishmaniasis case in a child male patient followed from 2016 to 2020, whose clinical isolates from multiple relapses were analyzed at genome level. To the best of our knowledge, it is the first report that both visceral leishmaniasis and non-ulcerated cutaneous leishmaniasis have concomitantly manifested in the same patient. Importantly, sequence analysis revealed that the patient was co-infected with Leishmania infantum and a Crithidia-related parasite, which was previously found in a fatal case of visceral leishmaniasis from the same endemic region.

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Rogerio LA, Takahashi TY, Cardoso L, Takamiya NT, de Melo EV, de Jesus AR et al. Co-infection of Leishmania infantum and a Crithidia-related species in a case of refractory relapsed visceral leishmaniasis with non-ulcerated cutaneous manifestation in Brazil. International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2023 May 12;133:85-88. doi: 10.1016/j.ijid.2023.05.012