Cold atmospheric pressure plasma jet interactions with plasmid DNA

TY - JOUR

T1 - Cold atmospheric pressure plasma jet interactions with plasmid DNA

AU - O'Connell, D.

AU - Cox, L. J.

AU - Hyland, W. B.

AU - McMahon, S. J.

AU - Reuter, S.

AU - Graham, W. G.

AU - Gans, T.

AU - Currell, F. J.

PY - 2011/1/24

Y1 - 2011/1/24

N2 - The effect of a cold (<40 degrees C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks. (C) 2011 American Institute of Physics. [doi:10.1063/1.3521502]

AB - The effect of a cold (<40 degrees C) radio frequency-driven atmospheric pressure plasma jet on plasmid DNA has been investigated. Gel electrophoresis was used to analyze the DNA forms post-treatment. The experimental data are fitted to a rate equation model that allows for quantitative determination of the rates of single and double strand break formation. The formation of double strand breaks correlates well with the atomic oxygen density. Taken with other measurements, this indicates that neutral components in the jet are effective in inducing double strand breaks. (C) 2011 American Institute of Physics. [doi:10.1063/1.3521502]

KW - STRAND

KW - MEDICINE

KW - SINGLE

UR - http://www.scopus.com/inward/record.url?scp=79551640545&partnerID=8YFLogxK

U2 - 10.1063/1.3521502

DO - 10.1063/1.3521502

M3 - Article

SN - 0003-6951

VL - 98

SP - 1

EP - 3

JO - Applied Physics Letters

JF - Applied Physics Letters

IS - 4

M1 - 043701

ER -