Combating mosquito-borne diseases using genetic control technologies

Guan Hong Wang; Stephanie Gamez; Robyn R. Raban; John M. Marshall; Luke Alphey; Ming Li; Jason L. Rasgon; Omar S. Akbari

doi:10.1038/s41467-021-24654-z

Combating mosquito-borne diseases using genetic control technologies

Guan Hong Wang, Stephanie Gamez, Robyn R. Raban, John M. Marshall, Luke Alphey, Ming Li, Jason L. Rasgon, Omar S. Akbari^*

^*Corresponding author for this work

Biology

Research output: Contribution to journal › Review article › peer-review

Abstract

Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.

Original language	English
Article number	4388
Journal	Nature Communications
Volume	12
Issue number	1
Early online date	19 Jul 2021
DOIs	https://doi.org/10.1038/s41467-021-24654-z
Publication status	Published - 1 Dec 2021

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Publisher Copyright:
© 2021, The Author(s).

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Cite this

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AU - Rasgon, Jason L.

AU - Akbari, Omar S.

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AB - Mosquito-borne diseases, such as dengue and malaria, pose significant global health burdens. Unfortunately, current control methods based on insecticides and environmental maintenance have fallen short of eliminating the disease burden. Scalable, deployable, genetic-based solutions are sought to reduce the transmission risk of these diseases. Pathogen-blocking Wolbachia bacteria, or genome engineering-based mosquito control strategies including gene drives have been developed to address these problems, both requiring the release of modified mosquitoes into the environment. Here, we review the latest developments, notable similarities, and critical distinctions between these promising technologies and discuss their future applications for mosquito-borne disease control.

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Combating mosquito-borne diseases using genetic control technologies

Abstract

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