Commensals, probiotics and pathogens in the Caenorhabditis elegans model

TY - JOUR

T1 - Commensals, probiotics and pathogens in the Caenorhabditis elegans model

AU - Clark, Laura C.

AU - Hodgkin, Jonathan

PY - 2014/1/1

Y1 - 2014/1/1

N2 - Summary: Caenorhabditis elegans is a useful model host for a wide variety of microorganisms that have implications for human health. Recent surveys of mammalian and metazoan microbiota demonstrate the often profound effects of gut commensal bacteria on host lifespan, health and development. Work using C.elegans has revealed the surprising extent to which bacterial metabolism can interact with host pathways with examples from Escherichia coli folate metabolism and Bacillus subtilis nitric oxide synthesis. The C.elegans model has also shed light on the mechanisms by which probiotic bacteria influence lifespan.

AB - Summary: Caenorhabditis elegans is a useful model host for a wide variety of microorganisms that have implications for human health. Recent surveys of mammalian and metazoan microbiota demonstrate the often profound effects of gut commensal bacteria on host lifespan, health and development. Work using C.elegans has revealed the surprising extent to which bacterial metabolism can interact with host pathways with examples from Escherichia coli folate metabolism and Bacillus subtilis nitric oxide synthesis. The C.elegans model has also shed light on the mechanisms by which probiotic bacteria influence lifespan.

UR - http://www.scopus.com/inward/record.url?scp=84890250693&partnerID=8YFLogxK

U2 - 10.1111/cmi.12234

DO - 10.1111/cmi.12234

M3 - Article

C2 - 24168639

AN - SCOPUS:84890250693

SN - 1462-5814

VL - 16

SP - 27

EP - 38

JO - Cellular Microbiology

JF - Cellular Microbiology

IS - 1

ER -