Commercially-Relevant Orthogonal Multi-Component Supramolecular Hydrogels for Programmed Cell Growth

Vania Margarida Pinto Vieira; Ana Catarina Lima; Menno de Jong; David Kelham Smith

doi:10.1002/chem.201803292

Commercially-Relevant Orthogonal Multi-Component Supramolecular Hydrogels for Programmed Cell Growth

Vania Margarida Pinto Vieira, Ana Catarina Lima, Menno de Jong, David Kelham Smith

Chemistry

Research output: Contribution to journal › Article › peer-review

Abstract

This study reports the ability of synthetically simple, commercially viable sugar-derived 1,3:2,4-dibenzylidenesorbitol-4’,4“-diacylhydrazide (DBS-CONHNH2) to support cell growth. Simple mixing and orthogonal self-sorting can formulate heparin, agarose, and heparin-binding micelles into these gels—easily incorporating additional function. Interestingly, the components used in the gel formulation, direct the ability of cells to grow, meaning the chemical programming of these multi-component gels is directly translated to the biological systems in contact with them. This simple approach has potential for future development
in regenerative medicine.

Original language	English
Pages (from-to)	15112-15118
Number of pages	15118
Journal	Chemistry : A European Journal
Volume	24
Issue number	56
Early online date	18 Jul 2018
DOIs	https://doi.org/10.1002/chem.201803292
Publication status	Published - 9 Oct 2018

Bibliographical note

© 2018 WILEY‐VCH Verlag. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

Access to Document

10.1002/chem.201803292

Vania CEJ Final Author Version
© 2018 WILEY‐VCH Verlag. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Accepted author manuscript, 1.03 MB
Vania CEJ ESI Revised
© 2018 WILEY‐VCH Verlag. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Accepted author manuscript, 2.93 MB

Cite this

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title = "Commercially-Relevant Orthogonal Multi-Component Supramolecular Hydrogels for Programmed Cell Growth",

abstract = "This study reports the ability of synthetically simple, commercially viable sugar-derived 1,3:2,4-dibenzylidenesorbitol-4{\textquoteright},4“-diacylhydrazide (DBS-CONHNH2) to support cell growth. Simple mixing and orthogonal self-sorting can formulate heparin, agarose, and heparin-binding micelles into these gels—easily incorporating additional function. Interestingly, the components used in the gel formulation, direct the ability of cells to grow, meaning the chemical programming of these multi-component gels is directly translated to the biological systems in contact with them. This simple approach has potential for future developmentin regenerative medicine.",

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