Commercially-Relevant Orthogonal Multi-Component Supramolecular Hydrogels for Programmed Cell Growth

Vania Margarida Pinto Vieira, Ana Catarina Lima, Menno de Jong, David Kelham Smith

Research output: Contribution to journalArticlepeer-review


This study reports the ability of synthetically simple, commercially viable sugar-derived 1,3:2,4-dibenzylidenesorbitol-4’,4“-diacylhydrazide (DBS-CONHNH2) to support cell growth. Simple mixing and orthogonal self-sorting can formulate heparin, agarose, and heparin-binding micelles into these gels—easily incorporating additional function. Interestingly, the components used in the gel formulation, direct the ability of cells to grow, meaning the chemical programming of these multi-component gels is directly translated to the biological systems in contact with them. This simple approach has potential for future development
in regenerative medicine.
Original languageEnglish
Pages (from-to)15112-15118
Number of pages15118
JournalChemistry : A European Journal
Issue number56
Early online date18 Jul 2018
Publication statusPublished - 9 Oct 2018

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© 2018 WILEY‐VCH Verlag. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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