Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis

F  Vincent; T M  Gloster; J  Macdonald; C  Morland; R V  Stick; F M V  Dias; J A M  Prates; C M G A  Fontes; H J  Gilbert; G J  Davies

doi:10.1002/cbic.200400169

Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis

F Vincent, T M Gloster, J Macdonald, C Morland, R V Stick, F M V Dias, J A M Prates, C M G A Fontes, H J Gilbert, G J Davies

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	1596-1599
Number of pages	4
Journal	Chembiochem
Volume	5
Issue number	11
DOIs	https://doi.org/10.1002/cbic.200400169
Publication status	Published - 5 Nov 2004

Keywords

carbohydrates
enzyme catalysis
glycosides
inhibitors
lactams
GLYCOSYL-ENZYME INTERMEDIATE
X-RAY CRYSTALLOGRAPHY
GLYCOSIDASE INHIBITORS
SUBSTRATE-SPECIFICITY
COVALENT-INTERMEDIATE
CRYSTAL-STRUCTURE
TRANSITION-STATE
KINETIC-ANALYSIS
MECHANISM
DISTORTION

Access to Document

10.1002/cbic.200400169

Cite this

Vincent, F., Gloster, T. M., Macdonald, J., Morland, C., Stick, R. V., Dias, F. M. V., Prates, J. A. M., Fontes, C. M. G. A., Gilbert, H. J., & Davies, G. J. (2004). Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis. Chembiochem, 5(11), 1596-1599. https://doi.org/10.1002/cbic.200400169

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keywords = "carbohydrates, enzyme catalysis, glycosides, inhibitors, lactams, GLYCOSYL-ENZYME INTERMEDIATE, X-RAY CRYSTALLOGRAPHY, GLYCOSIDASE INHIBITORS, SUBSTRATE-SPECIFICITY, COVALENT-INTERMEDIATE, CRYSTAL-STRUCTURE, TRANSITION-STATE, KINETIC-ANALYSIS, MECHANISM, DISTORTION",

author = "F Vincent and Gloster, {T M} and J Macdonald and C Morland and Stick, {R V} and Dias, {F M V} and Prates, {J A M} and Fontes, {C M G A} and Gilbert, {H J} and Davies, {G J}",

year = "2004",

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doi = "10.1002/cbic.200400169",

language = "English",

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Vincent, F, Gloster, TM, Macdonald, J, Morland, C, Stick, RV, Dias, FMV, Prates, JAM, Fontes, CMGA, Gilbert, HJ & Davies, GJ 2004, 'Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis', Chembiochem, vol. 5, no. 11, pp. 1596-1599. https://doi.org/10.1002/cbic.200400169

TY - JOUR

T1 - Common inhibition of both beta-glucosidases and beta-mannosidases by isofagomine lactam reflects different conformational itineraries for pyranoside hydrolysis

AU - Vincent, F

AU - Gloster, T M

AU - Macdonald, J

AU - Morland, C

AU - Stick, R V

AU - Dias, F M V

AU - Prates, J A M

AU - Fontes, C M G A

AU - Gilbert, H J

AU - Davies, G J

PY - 2004/11/5

Y1 - 2004/11/5

KW - carbohydrates

KW - enzyme catalysis

KW - glycosides

KW - inhibitors

KW - lactams

KW - GLYCOSYL-ENZYME INTERMEDIATE

KW - X-RAY CRYSTALLOGRAPHY

KW - GLYCOSIDASE INHIBITORS

KW - SUBSTRATE-SPECIFICITY

KW - COVALENT-INTERMEDIATE

KW - CRYSTAL-STRUCTURE

KW - TRANSITION-STATE

KW - KINETIC-ANALYSIS

KW - MECHANISM

KW - DISTORTION

U2 - 10.1002/cbic.200400169

DO - 10.1002/cbic.200400169

M3 - Article

SN - 1439-4227

VL - 5

SP - 1596

EP - 1599

JO - Chembiochem

JF - Chembiochem

IS - 11

ER -