Competing time-to-event endpoints in cardiology trials: A simulation study to illustrate the importance of an adequate statistical analysis

Geraldine Rauch, Meinhard Kieser, Sandra Ulrich, Patrick Doherty, Bernhard Rauch, Steffen Schneider, Thomas Riemer, Jochen Senges

Research output: Contribution to journalArticlepeer-review


Clinical trials in cardiology commonly consider time-to-event endpoints that are often influenced by competing risks. In the presence of competing risks, standard survival analysis techniques, such as the Kaplan-Meier estimator, can yield seriously biased results. Although methods to account for competing risks are well known in the statistical literature, they are rarely applied in clinical trials.
Original languageEnglish
Pages (from-to)74-80
Number of pages7
JournalEuropean journal of preventive cardiology
Issue number1
Early online date10 Sept 2012
Publication statusPublished - Jan 2014

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