By the same authors

Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis

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Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis. / Gollnick, P ; Babitzke, P ; Antson, A ; Yanofsky, C .

In: ANNUAL REVIEW OF GENETICS, Vol. 39, 2005, p. 47-68.

Research output: Contribution to journalLiterature reviewpeer-review

Harvard

Gollnick, P, Babitzke, P, Antson, A & Yanofsky, C 2005, 'Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis', ANNUAL REVIEW OF GENETICS, vol. 39, pp. 47-68. https://doi.org/10.1146/annurev.genet.39.073003.093745

APA

Gollnick, P., Babitzke, P., Antson, A., & Yanofsky, C. (2005). Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis. ANNUAL REVIEW OF GENETICS, 39, 47-68. https://doi.org/10.1146/annurev.genet.39.073003.093745

Vancouver

Gollnick P, Babitzke P, Antson A, Yanofsky C. Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis. ANNUAL REVIEW OF GENETICS. 2005;39:47-68. https://doi.org/10.1146/annurev.genet.39.073003.093745

Author

Gollnick, P ; Babitzke, P ; Antson, A ; Yanofsky, C . / Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis. In: ANNUAL REVIEW OF GENETICS. 2005 ; Vol. 39. pp. 47-68.

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@article{1f7aa96bed0646c7a5cc16a5943b0e5b,
title = "Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis",
abstract = "Bacillus subtilis uses novel regulatory mechanisms in controlling expression of its genes of tryptophan synthesis and transport. These mechanisms respond to changes in the intracellular concentrations of free tryptophan and uncharged tRNA(Trp). The major B. subtilis protein that regulates tryptophan biosynthesis is the tryptophan-activated RNA-binding attenuation protein TRAP TRAP is a ring- shaped molecule composed of 11 identical subunits. Active TRAP binds to unique RNA segments containing multiple trinucleotide (NAG) repeats. Binding regulates both transcription termination and translation in the trp operon, and translation of other coding regions relevant to tryptophan metabolism. When there is a deficiency of charged tRNA(Trp), B. subtilis forms an anti-TRAP protein, AT. AT antagonizes TRAP function, thereby increasing expression of all the genes regulated by TRAP. Thus B. subtilis and Escherochia coli respond to identical regulatory signals, tryptophan and uncharged tRNA(Trp), yet they employ different mechanisms in regulating trp gene expression.",
keywords = "trp operon regulation, attenuation, tryptophan sensing, tRNA(Trp) sensing, TRAP regulatory protein, AT regulatory protein, BINDING ATTENUATION PROTEIN, TRP LEADER RNA, TRANSCRIPTION ATTENUATION, ANTI-TRAP, TRPEDCFBA OPERON, ACID BIOSYNTHESIS, ESCHERICHIA-COLI, RIBOSOME BINDING, UNKNOWN FUNCTION, MUTANT SUBUNITS",
author = "P Gollnick and P Babitzke and A Antson and C Yanofsky",
year = "2005",
doi = "10.1146/annurev.genet.39.073003.093745",
language = "English",
volume = "39",
pages = "47--68",
journal = "ANNUAL REVIEW OF GENETICS",
issn = "0066-4197",
publisher = "Annual Reviews Inc.",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Complexity in regulation of tryptophan biosynthesis in Bacillus subtilis

AU - Gollnick, P

AU - Babitzke, P

AU - Antson, A

AU - Yanofsky, C

PY - 2005

Y1 - 2005

N2 - Bacillus subtilis uses novel regulatory mechanisms in controlling expression of its genes of tryptophan synthesis and transport. These mechanisms respond to changes in the intracellular concentrations of free tryptophan and uncharged tRNA(Trp). The major B. subtilis protein that regulates tryptophan biosynthesis is the tryptophan-activated RNA-binding attenuation protein TRAP TRAP is a ring- shaped molecule composed of 11 identical subunits. Active TRAP binds to unique RNA segments containing multiple trinucleotide (NAG) repeats. Binding regulates both transcription termination and translation in the trp operon, and translation of other coding regions relevant to tryptophan metabolism. When there is a deficiency of charged tRNA(Trp), B. subtilis forms an anti-TRAP protein, AT. AT antagonizes TRAP function, thereby increasing expression of all the genes regulated by TRAP. Thus B. subtilis and Escherochia coli respond to identical regulatory signals, tryptophan and uncharged tRNA(Trp), yet they employ different mechanisms in regulating trp gene expression.

AB - Bacillus subtilis uses novel regulatory mechanisms in controlling expression of its genes of tryptophan synthesis and transport. These mechanisms respond to changes in the intracellular concentrations of free tryptophan and uncharged tRNA(Trp). The major B. subtilis protein that regulates tryptophan biosynthesis is the tryptophan-activated RNA-binding attenuation protein TRAP TRAP is a ring- shaped molecule composed of 11 identical subunits. Active TRAP binds to unique RNA segments containing multiple trinucleotide (NAG) repeats. Binding regulates both transcription termination and translation in the trp operon, and translation of other coding regions relevant to tryptophan metabolism. When there is a deficiency of charged tRNA(Trp), B. subtilis forms an anti-TRAP protein, AT. AT antagonizes TRAP function, thereby increasing expression of all the genes regulated by TRAP. Thus B. subtilis and Escherochia coli respond to identical regulatory signals, tryptophan and uncharged tRNA(Trp), yet they employ different mechanisms in regulating trp gene expression.

KW - trp operon regulation

KW - attenuation

KW - tryptophan sensing

KW - tRNA(Trp) sensing

KW - TRAP regulatory protein

KW - AT regulatory protein

KW - BINDING ATTENUATION PROTEIN

KW - TRP LEADER RNA

KW - TRANSCRIPTION ATTENUATION

KW - ANTI-TRAP

KW - TRPEDCFBA OPERON

KW - ACID BIOSYNTHESIS

KW - ESCHERICHIA-COLI

KW - RIBOSOME BINDING

KW - UNKNOWN FUNCTION

KW - MUTANT SUBUNITS

U2 - 10.1146/annurev.genet.39.073003.093745

DO - 10.1146/annurev.genet.39.073003.093745

M3 - Literature review

VL - 39

SP - 47

EP - 68

JO - ANNUAL REVIEW OF GENETICS

JF - ANNUAL REVIEW OF GENETICS

SN - 0066-4197

ER -