Research output: Contribution to journal › Article › peer-review
Journal | IET Systems Biology |
---|---|
Date | E-pub ahead of print - 21 Aug 2015 |
Date | Published (current) - Dec 2015 |
Issue number | 6 |
Volume | 9 |
Number of pages | 8 |
Pages (from-to) | 226-233 |
Early online date | 21/08/15 |
Original language | English |
This study describes how the application of evolutionary algorithms (EAs) can be used to study motor function in humans with Parkinson's disease (PD) and in animal models of PD. Human data is obtained using commercially available sensors via a range of non-invasive procedures that follow conventional clinical practice. EAs can then be used to classify human data for a range of uses, including diagnosis and disease monitoring. New results are presented that demonstrate how EAs can also be used to classify fruit flies with and without genetic mutations that cause Parkinson's by using measurements of the proboscis extension reflex. The case is made for a computational approach that can be applied across human and animal studies of PD and lays the way for evaluation of existing and new drug therapies in a truly objective way.
Project: Other project › Other internal award
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