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Computational challenges in the analysis of ancient DNA

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JournalGenome biology
DatePublished - 6 May 2010
Issue number5
Volume11
Number of pages15
Pages (from-to)-
Original languageEnglish

Abstract

High-throughput sequencing technologies have opened up a new avenue for studying extinct organisms. Here we identify and quantify biases introduced by particular characteristics of ancient DNA samples. These analyses demonstrate the importance of closely related genomic sequence for correctly identifying and classifying bona fide endogenous DNA fragments. We show that more accurate genome divergence estimates from ancient DNA sequence can be attained using at least two outgroup genomes and appropriate filtering.

    Research areas

  • MITOCHONDRIAL GENOME, NEANDERTHAL GENOME, SEQUENCE, EVOLUTION, MAMMOTH, MOUSE, BLAST, AMPLIFICATION, ALIGNMENTS, PHYLOGENY

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