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Computational models of signalling networks for non-linear control

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JournalBiosystems
DatePublished - May 2013
Issue number2
Volume112
Pages (from-to)122-130
Original languageEnglish

Abstract

Artificial signalling networks (ASNs) are a computational approach inspired by the signalling processes inside cells that decode outside environmental information. Using evolutionary algorithms to induce complex behaviours, we show how chaotic dynamics in a conservative dynamical system can be controlled. Such dynamics are of particular interest as they mimic the inherent complexity of non-linear physical systems in the real world. Considering the main biological interpretations of cellular signalling, in which complex behaviours and robust cellular responses emerge from the interaction of multiple pathways, we introduce two ASN representations: a stand-alone ASN and a coupled ASN. In particular we note how sophisticated cellular communication mechanisms can lead to effective controllers, where complicated problems can be divided into smaller and independent tasks.

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Copyright © 2013 Elsevier Ireland Ltd. All rights reserved.

    Research areas

  • Algorithms, Animals, Biological Evolution, Cell Communication, Computer Simulation, Humans, Kinetics, Models, Biological, Nonlinear Dynamics, Signal Transduction

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