By the same authors

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From the same journal

Condition-Dependent Transcriptome Reveals High-Level Regulatory Architecture in Bacillus subtilis

Research output: Contribution to journalArticle

Author(s)

  • Pierre Nicolas
  • Ulrike Maeder
  • Etienne Dervyn
  • Tatiana Rochat
  • Aurelie Leduc
  • Nathalie Pigeonneau
  • Elena Bidnenko
  • Elodie Marchadier
  • Mark Hoebeke
  • Stephane Aymerich
  • Doerte Becher
  • Paola Bisicchia
  • Eric Botella
  • Olivier Delumeau
  • Geoff Doherty
  • Emma L. Denham
  • Vincent Fromion
  • Anne Goelzer
  • Annette Hansen
  • Elisabeth Haertig
  • Colin R. Harwood
  • Georg Homuth
  • Hanne Jarmer
  • Matthieu Jules
  • Edda Klipp
  • Ludovic Le Chat
  • Francois Lecointe
  • Peter Lewis
  • Wolfram Liebermeister
  • Anika March
  • Ruben A. T. Mars
  • Priyanka Nannapaneni
  • David Noone
  • Susanne Pohl
  • Bernd Rinn
  • Frank Ruegheimer
  • Praveen K. Sappa
  • Franck Samson
  • Marc Schaffer
  • Benno Schwikowski
  • Leif Steil
  • Joerg Stuelke
  • Thomas Wiegert
  • Kevin M. Devine
  • Jan Maarten van Dijl
  • Michael Hecker
  • Uwe Voelker
  • Philippe Bessieres
  • Philippe Noirot

Department/unit(s)

Publication details

JournalScience
DatePublished - 2 Mar 2012
Issue number6072
Volume335
Number of pages4
Pages (from-to)1103-1106
Original languageEnglish

Abstract

Bacteria adapt to environmental stimuli by adjusting their transcriptomes in a complex manner, the full potential of which has yet to be established for any individual bacterial species. Here, we report the transcriptomes of Bacillus subtilis exposed to a wide range of environmental and nutritional conditions that the organism might encounter in nature. We comprehensively mapped transcription units (TUs) and grouped 2935 promoters into regulons controlled by various RNA polymerase sigma factors, accounting for similar to 66% of the observed variance in transcriptional activity. This global classification of promoters and detailed description of TUs revealed that a large proportion of the detected antisense RNAs arose from potentially spurious transcription initiation by alternative sigma factors and from imperfect control of transcription termination.

Projects

  • BaSysBio

    Project: Research project (funded)Research

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