Conformational and Electronic Variations in 1,2- and 1,6-Cyclophellitols and Their Impact on Retaining α-Glucosidase Inhibition

Tim P. Ofman; Jurriaan J. A. Heming; Alba Nin-Hill; Florian Küllmer; Elisha Moran; Megan Bennett; Roy Steneker; Anne-Mei Klein; Gijs Ruijgrok; Ken Kok; Zach W. B. Armstrong; Johannes M. F. G. Aerts; Gijsbert A. van der Marel; Carme Rovira; Gideon J. Davies; Marta Artola; Jeroen D. C. Codée; Herman S Overkleeft.

doi:10.1002/chem.202400723

Conformational and Electronic Variations in 1,2- and 1,6-Cyclophellitols and Their Impact on Retaining α-Glucosidase Inhibition

Tim P. Ofman, Jurriaan J. A. Heming, Alba Nin-Hill, Florian Küllmer, Elisha Moran, Megan Bennett, Roy Steneker, Anne-Mei Klein, Gijs Ruijgrok, Ken Kok, Zach W. B. Armstrong, Johannes M. F. G. Aerts, Gijsbert A. van der Marel, Carme Rovira, Gideon J. Davies, Marta Artola, Jeroen D. C. Codée, Herman S Overkleeft.

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Number of pages	10
Journal	Chemistry - A European Journal
Early online date	16 Apr 2024
DOIs	https://doi.org/10.1002/chem.202400723
Publication status	E-pub ahead of print - 16 Apr 2024

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10.1002/chem.202400723Licence: CC BY

Chemistry A European J - 2024 - Ofman - Conformational and Electronic Variations in 1 2‐ and 1 5a‐Cyclophellitols and their
© 2024 The Authors
Final published version, 3.55 MBLicence: CC BY

1 Finished
2 Active

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society
Davies, G. J.
EUROPEAN COMMISSION
1/06/21 → 31/05/27
Project: Research project (funded) › Research
RS Research Professorship
Davies, G. J.
THE ROYAL SOCIETY
1/01/17 → 31/12/27
Project: Research project (funded) › Research
X-ray Diffraction Equipment for Macromolecular Crystallography at York
Davies, G. J., Antson, A. A., Brzozowski, A. M., Cowtan, K., Fascione, M. A., Grogan, G. J., Plevin, M. J., Thomas, G. H., Wilkinson, A. J., Willems, L. I. & Wilson, K. S.
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
18/09/20 → 17/09/22
Project: Research project (funded) › Research

Cite this

Ofman, T. P., Heming, J. J. A., Nin-Hill, A., Küllmer, F., Moran, E., Bennett, M., Steneker, R., Klein, A.-M., Ruijgrok, G., Kok, K., Armstrong, Z. W. B., Aerts, J. M. F. G., van der Marel, G. A., Rovira, C., Davies, G. J., Artola, M., Codée, J. D. C., & Overkleeft., H. S. (2024). Conformational and Electronic Variations in 1,2- and 1,6-Cyclophellitols and Their Impact on Retaining α-Glucosidase Inhibition. Chemistry - A European Journal. Advance online publication. https://doi.org/10.1002/chem.202400723

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title = "Conformational and Electronic Variations in 1,2- and 1,6-Cyclophellitols and Their Impact on Retaining α-Glucosidase Inhibition",

author = "Ofman, {Tim P.} and Heming, {Jurriaan J. A.} and Alba Nin-Hill and Florian K{\"u}llmer and Elisha Moran and Megan Bennett and Roy Steneker and Anne-Mei Klein and Gijs Ruijgrok and Ken Kok and Armstrong, {Zach W. B.} and Aerts, {Johannes M. F. G.} and {van der Marel}, {Gijsbert A.} and Carme Rovira and Davies, {Gideon J.} and Marta Artola and Cod{\'e}e, {Jeroen D. C.} and Overkleeft., {Herman S}",

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Ofman, TP, Heming, JJA, Nin-Hill, A, Küllmer, F, Moran, E, Bennett, M, Steneker, R, Klein, A-M, Ruijgrok, G, Kok, K, Armstrong, ZWB, Aerts, JMFG, van der Marel, GA, Rovira, C, Davies, GJ, Artola, M, Codée, JDC & Overkleeft., HS 2024, 'Conformational and Electronic Variations in 1,2- and 1,6-Cyclophellitols and Their Impact on Retaining α-Glucosidase Inhibition', Chemistry - A European Journal. https://doi.org/10.1002/chem.202400723

TY - JOUR

T1 - Conformational and Electronic Variations in 1,2- and 1,6-Cyclophellitols and Their Impact on Retaining α-Glucosidase Inhibition

AU - Ofman, Tim P.

AU - Heming, Jurriaan J. A.

AU - Nin-Hill, Alba

AU - Küllmer, Florian

AU - Moran, Elisha

AU - Bennett, Megan

AU - Steneker, Roy

AU - Klein, Anne-Mei

AU - Ruijgrok, Gijs

AU - Kok, Ken

AU - Armstrong, Zach W. B.

AU - Aerts, Johannes M. F. G.

AU - van der Marel, Gijsbert A.

AU - Rovira, Carme

AU - Davies, Gideon J.

AU - Artola, Marta

AU - Codée, Jeroen D. C.

AU - Overkleeft., Herman S

PY - 2024/4/16

Y1 - 2024/4/16

U2 - 10.1002/chem.202400723

DO - 10.1002/chem.202400723

M3 - Article

SN - 0947-6539

JO - Chemistry - A European Journal

JF - Chemistry - A European Journal

ER -

Conformational and Electronic Variations in 1,2- and 1,6-Cyclophellitols and Their Impact on Retaining α-Glucosidase Inhibition

Bibliographical note

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Projects

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society

RS Research Professorship

X-ray Diffraction Equipment for Macromolecular Crystallography at York

Cite this