By the same authors

From the same journal

From the same journal

Consequences of a multi-generation exposure to uranium on Caenorhabditis elegans life parameters and sensitivity

Research output: Contribution to journalArticle


  • Benoit Goussen
  • Florian Parisot
  • Rémy Beaudouin
  • Morgan Dutilleul
  • Adeline Buisset-Goussen
  • Alexandre R R Péry
  • Jean-Marc Bonzom


Publication details

DateE-pub ahead of print - 14 May 2013
DatePublished (current) - Jul 2013
Issue number5
Number of pages10
Pages (from-to)869-78
Early online date14/05/13
Original languageEnglish


The assessment of toxic effects at biologically and ecologically relevant scales is an important challenge in ecosystem protection. Indeed, stressors may impact populations at much longer term than the usual timescale of toxicity tests. It is therefore important to study the evolutionary response of a population under chronic stress. We performed a 16-generation study to assess the evolution of two populations of the ubiquitous nematode Caenorhabditis elegans in control conditions or exposed to 1.1 mM of uranium. Several generations were selected to assess growth, reproduction, survival, and dose-responses relationships, through exposure to a range of concentrations (from 0 to 1.2 mM U) with all endpoints measured daily. Our experiment showed an adaptation of individuals to experimental conditions (increase of maximal length and decrease of fecundity) for both populations. We also observed an increase of adverse effects (reduction of growth and fertility) as a function of uranium concentration. We pointed out the emergence of population differentiation for reproduction traits. In contrast, no differentiation was observed on growth traits. Our results confirm the importance of assessing environmental risk related to pollutant through multi-generational studies.

    Research areas

  • Adaptation, Physiological, Animals, Body Size, Caenorhabditis elegans, Dose-Response Relationship, Drug, Environmental Pollutants, Fertility, Gene-Environment Interaction, Life Cycle Stages, Longevity, Reproduction, Risk Assessment, Uranium Compounds

Discover related content

Find related publications, people, projects, datasets and more using interactive charts.

View graph of relations