By the same authors

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Controlled Release of DNA From Photoresponsive Hyperbranched Polyglycerols with Oligoamine Shells

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Published copy (DOI)

Author(s)

  • Wiebke Fischer
  • Mohiuddin A. Quadir
  • Anna Barnard
  • David K. Smith
  • Rainer Haag

Department/unit(s)

Publication details

JournalMacromolecular bioscience
DatePublished - 8 Dec 2011
Issue number12
Volume11
Number of pages11
Pages (from-to)1736-1746
Original languageEnglish

Abstract

Two photo-responsive core/shell nanoparticles based on hyperbranched polyglycerol (hPG) are synthesized for controlled release of DNA. The shell is composed either of bis-(3-aminopropyl)methylamine (AMPA) or pentaethylenehexamine (PEHA) derivatives and is attached to the hPG core with a photo-responsive o-nitrobenzyl linker. Ethidium bromide displacement assay, gel electrophoresis, DLS, and ?-potential measurements are performed with these nanoparticles. Photo-responsive changes within the carrier scaffold are investigated by irradiating the polymer solution with 350?nm monochromatic light. Fully covered APMA-shelled carriers are found to complex the DNA at an N/P ratio of 10 with an average size ranging from 54 to 78?nm depending on the degree of functionalization of the core.

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