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Co-ordinated changes in expression of cell adhesion molecules in prostate cancer

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JournalEuropean Journal of Cancer
DatePublished - Feb 1997
Issue number2
Volume33
Number of pages9
Pages (from-to)263-271
Original languageEnglish

Abstract

The expressions of E-cadherin, the integrin subunits beta(1), beta(2), beta(3), CD44 and alpha-catenin were studied in parallel by immunohistochemistry in a series of 40 prostate biopsies comprising one normal, 11 benign prostatic hyperplasia (BPH), and 28 prostatic adenocarcinomas. As reported by others, there was a consistent loss of E-cadherin expression with increasing tumour grade and de-differentiation. However, a significant proportion of losses occurred at earlier grades than previously reported. The parallel nature of this study showed, for the first time in human prostate carcinoma, a reciprocal expression pattern of E-cadherin and beta(1) integrin in the higher grades of prostate cancer. A reciprocal expression pattern was also found for E-cadherin and CD44 between moderately and poorly differentiated tumours. alpha-Catenin expression was downregulated only in those cells which had previously lost E-cadherin expression, and beta(2) and beta(3) integrin were rarely expressed in prostate tumours. A loss of expression of the luminal epithelial specific keratins CK8 and CK18 was also observed in advanced stage, poorly differentiated carcinomas. (C) 1997 Elsevier Science Ltd.

    Research areas

  • prostate cancer, adhesion molecules, integrin, cadherin, catenin, CD44, E-CADHERIN, DIFFERENTIAL EXPRESSION, NEOPLASTIC PROSTATE, GENETIC CHANGES, METASTASIS, INTEGRINS, CARCINOMA, PROTEINS, LINES

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