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Co-ordinated changes in expression of cell adhesion molecules in prostate cancer

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Co-ordinated changes in expression of cell adhesion molecules in prostate cancer. / Murant, S J; Handley, J; Stower, M; Reid, N; Cussenot, O; Maitland, N J.

In: European Journal of Cancer, Vol. 33, No. 2, 02.1997, p. 263-271.

Research output: Contribution to journalArticlepeer-review

Harvard

Murant, SJ, Handley, J, Stower, M, Reid, N, Cussenot, O & Maitland, NJ 1997, 'Co-ordinated changes in expression of cell adhesion molecules in prostate cancer', European Journal of Cancer, vol. 33, no. 2, pp. 263-271.

APA

Murant, S. J., Handley, J., Stower, M., Reid, N., Cussenot, O., & Maitland, N. J. (1997). Co-ordinated changes in expression of cell adhesion molecules in prostate cancer. European Journal of Cancer, 33(2), 263-271.

Vancouver

Murant SJ, Handley J, Stower M, Reid N, Cussenot O, Maitland NJ. Co-ordinated changes in expression of cell adhesion molecules in prostate cancer. European Journal of Cancer. 1997 Feb;33(2):263-271.

Author

Murant, S J ; Handley, J ; Stower, M ; Reid, N ; Cussenot, O ; Maitland, N J. / Co-ordinated changes in expression of cell adhesion molecules in prostate cancer. In: European Journal of Cancer. 1997 ; Vol. 33, No. 2. pp. 263-271.

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@article{320cdca4fe58447d90d870a5ae00367b,
title = "Co-ordinated changes in expression of cell adhesion molecules in prostate cancer",
abstract = "The expressions of E-cadherin, the integrin subunits beta(1), beta(2), beta(3), CD44 and alpha-catenin were studied in parallel by immunohistochemistry in a series of 40 prostate biopsies comprising one normal, 11 benign prostatic hyperplasia (BPH), and 28 prostatic adenocarcinomas. As reported by others, there was a consistent loss of E-cadherin expression with increasing tumour grade and de-differentiation. However, a significant proportion of losses occurred at earlier grades than previously reported. The parallel nature of this study showed, for the first time in human prostate carcinoma, a reciprocal expression pattern of E-cadherin and beta(1) integrin in the higher grades of prostate cancer. A reciprocal expression pattern was also found for E-cadherin and CD44 between moderately and poorly differentiated tumours. alpha-Catenin expression was downregulated only in those cells which had previously lost E-cadherin expression, and beta(2) and beta(3) integrin were rarely expressed in prostate tumours. A loss of expression of the luminal epithelial specific keratins CK8 and CK18 was also observed in advanced stage, poorly differentiated carcinomas. (C) 1997 Elsevier Science Ltd.",
keywords = "prostate cancer, adhesion molecules, integrin, cadherin, catenin, CD44, E-CADHERIN, DIFFERENTIAL EXPRESSION, NEOPLASTIC PROSTATE, GENETIC CHANGES, METASTASIS, INTEGRINS, CARCINOMA, PROTEINS, LINES",
author = "Murant, {S J} and J Handley and M Stower and N Reid and O Cussenot and Maitland, {N J}",
year = "1997",
month = feb,
language = "English",
volume = "33",
pages = "263--271",
journal = "European Journal of Cancer",
issn = "0959-8049",
publisher = "Elsevier Limited",
number = "2",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Co-ordinated changes in expression of cell adhesion molecules in prostate cancer

AU - Murant, S J

AU - Handley, J

AU - Stower, M

AU - Reid, N

AU - Cussenot, O

AU - Maitland, N J

PY - 1997/2

Y1 - 1997/2

N2 - The expressions of E-cadherin, the integrin subunits beta(1), beta(2), beta(3), CD44 and alpha-catenin were studied in parallel by immunohistochemistry in a series of 40 prostate biopsies comprising one normal, 11 benign prostatic hyperplasia (BPH), and 28 prostatic adenocarcinomas. As reported by others, there was a consistent loss of E-cadherin expression with increasing tumour grade and de-differentiation. However, a significant proportion of losses occurred at earlier grades than previously reported. The parallel nature of this study showed, for the first time in human prostate carcinoma, a reciprocal expression pattern of E-cadherin and beta(1) integrin in the higher grades of prostate cancer. A reciprocal expression pattern was also found for E-cadherin and CD44 between moderately and poorly differentiated tumours. alpha-Catenin expression was downregulated only in those cells which had previously lost E-cadherin expression, and beta(2) and beta(3) integrin were rarely expressed in prostate tumours. A loss of expression of the luminal epithelial specific keratins CK8 and CK18 was also observed in advanced stage, poorly differentiated carcinomas. (C) 1997 Elsevier Science Ltd.

AB - The expressions of E-cadherin, the integrin subunits beta(1), beta(2), beta(3), CD44 and alpha-catenin were studied in parallel by immunohistochemistry in a series of 40 prostate biopsies comprising one normal, 11 benign prostatic hyperplasia (BPH), and 28 prostatic adenocarcinomas. As reported by others, there was a consistent loss of E-cadherin expression with increasing tumour grade and de-differentiation. However, a significant proportion of losses occurred at earlier grades than previously reported. The parallel nature of this study showed, for the first time in human prostate carcinoma, a reciprocal expression pattern of E-cadherin and beta(1) integrin in the higher grades of prostate cancer. A reciprocal expression pattern was also found for E-cadherin and CD44 between moderately and poorly differentiated tumours. alpha-Catenin expression was downregulated only in those cells which had previously lost E-cadherin expression, and beta(2) and beta(3) integrin were rarely expressed in prostate tumours. A loss of expression of the luminal epithelial specific keratins CK8 and CK18 was also observed in advanced stage, poorly differentiated carcinomas. (C) 1997 Elsevier Science Ltd.

KW - prostate cancer

KW - adhesion molecules

KW - integrin

KW - cadherin

KW - catenin

KW - CD44

KW - E-CADHERIN

KW - DIFFERENTIAL EXPRESSION

KW - NEOPLASTIC PROSTATE

KW - GENETIC CHANGES

KW - METASTASIS

KW - INTEGRINS

KW - CARCINOMA

KW - PROTEINS

KW - LINES

M3 - Article

VL - 33

SP - 263

EP - 271

JO - European Journal of Cancer

JF - European Journal of Cancer

SN - 0959-8049

IS - 2

ER -