Coordinated control of the gene expression machinery

R.J. White; A.D. Sharrocks

doi:10.1016/j.tig.2010.02.004

Coordinated control of the gene expression machinery

R.J. White, A.D. Sharrocks

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Gene expression is a multi-step process starting from transcribing DNA through to the eventual production of proteins or RNA products. It is important that this process is controlled coordinately to ensure that all steps function in a concerted manner. Signal transduction pathways orchestrate such control and bring about wholesale changes in the gene expression profiles of cells that ultimately determine their phenotype. Recent studies on the MAP kinase and mTOR signaling pathways in mammalian cells have illustrated how integrated responses to signaling pathways are achieved. This occurs at both the transcriptional level, through the coordinate regulation of RNA polymerases I-III and downstream in the coordinate regulation of transcription with RNA processing and translation.

Original language	English
Pages (from-to)	214-220
Number of pages	7
Journal	Trends in Genetics
Volume	26
Issue number	5
DOIs	https://doi.org/10.1016/j.tig.2010.02.004
Publication status	Published - 1 May 2010

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10.1016/j.tig.2010.02.004

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Coordinated control of the gene expression machinery

Abstract

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