By the same authors

From the same journal

Coping style and depression influence the healing of diabetic foot ulcers: observational and mechanistic evidence

Research output: Contribution to journalArticle

Standard

Coping style and depression influence the healing of diabetic foot ulcers : observational and mechanistic evidence. / Vedhara, K.; Miles, J. N. V.; Wetherell, M. A.; Dawe, K.; Searle, A.; Tallon, D.; Cullum, N.; Day, A.; Dayan, C.; Drake, N.; Price, P.; Tarlton, J.; Weinman, J.; Campbell, R.

In: DIABETOLOGIA, Vol. 53, No. 8, 08.2010, p. 1590-1598.

Research output: Contribution to journalArticle

Harvard

Vedhara, K, Miles, JNV, Wetherell, MA, Dawe, K, Searle, A, Tallon, D, Cullum, N, Day, A, Dayan, C, Drake, N, Price, P, Tarlton, J, Weinman, J & Campbell, R 2010, 'Coping style and depression influence the healing of diabetic foot ulcers: observational and mechanistic evidence', DIABETOLOGIA, vol. 53, no. 8, pp. 1590-1598. https://doi.org/10.1007/s00125-010-1743-7

APA

Vedhara, K., Miles, J. N. V., Wetherell, M. A., Dawe, K., Searle, A., Tallon, D., ... Campbell, R. (2010). Coping style and depression influence the healing of diabetic foot ulcers: observational and mechanistic evidence. DIABETOLOGIA, 53(8), 1590-1598. https://doi.org/10.1007/s00125-010-1743-7

Vancouver

Vedhara K, Miles JNV, Wetherell MA, Dawe K, Searle A, Tallon D et al. Coping style and depression influence the healing of diabetic foot ulcers: observational and mechanistic evidence. DIABETOLOGIA. 2010 Aug;53(8):1590-1598. https://doi.org/10.1007/s00125-010-1743-7

Author

Vedhara, K. ; Miles, J. N. V. ; Wetherell, M. A. ; Dawe, K. ; Searle, A. ; Tallon, D. ; Cullum, N. ; Day, A. ; Dayan, C. ; Drake, N. ; Price, P. ; Tarlton, J. ; Weinman, J. ; Campbell, R. / Coping style and depression influence the healing of diabetic foot ulcers : observational and mechanistic evidence. In: DIABETOLOGIA. 2010 ; Vol. 53, No. 8. pp. 1590-1598.

Bibtex - Download

@article{41e85560964b4f7da9a74bc7ccb88120,
title = "Coping style and depression influence the healing of diabetic foot ulcers: observational and mechanistic evidence",
abstract = "Experimental evidence suggests that the healing of diabetic foot ulcers is affected by psychosocial factors such as distress. We examined this proposal in a prospective study, in which we considered the role of psychological distress and coping style in the healing of diabetic foot ulcers over a 24 week period. We also explored the role of salivary cortisol and matrix metalloproteinases (MMPs) as potential mechanisms.For this prospective observational study we recruited 93 (68 men; mean age 60 years) patients with neuropathic or neuroischaemic diabetic foot ulcers from specialist podiatry clinics in secondary care. Clinical and demographic determinants of healing, psychological distress, coping, salivary cortisol and both MMP2 and MMP9 were assessed at baseline. Ulcers were assessed at baseline and at 6, 12 and 24 weeks post-baseline. The primary outcome was ulcer status at 24 weeks, i.e. healed vs not healed.After controlling for clinical and demographic determinants of healing, ulcer healing at 24 weeks was predicted by confrontation coping, but not by depression or anxiety. Patients with unhealed ulcers exhibited greater confrontation coping (model including depression: OR 0.809, 95{\%} CI 0.704-0.929, p = 0.003; model including anxiety: OR 0.810, 95{\%} CI 0.704-0.930, p = 0.003). However, change in ulcer size over the observation period was associated with depression only (p = 0.04, d = 0.31). Healed ulcers by 24 weeks were also associated with lower evening cortisol, higher precursor MMP2 and a greater cortisol awakening response.Confrontation coping and depression predict ulcer healing. Our preliminary enquiry into biological mechanisms suggests that cortisol and precursor MMP2 may underlie these relationships.",
keywords = "Coping, Cortisol, Depression, Diabetic foot ulcers, Healing, MMPs, Prospective, Psychological distress, TRANSMISSION DENSITOMETRY, GLYCEMIC CONTROL, CHRONIC WOUNDS, STRESS, CORTISOL, COHORT, POPULATION, PROGRESSION, EXPRESSION, MELLITUS",
author = "K. Vedhara and Miles, {J. N. V.} and Wetherell, {M. A.} and K. Dawe and A. Searle and D. Tallon and N. Cullum and A. Day and C. Dayan and N. Drake and P. Price and J. Tarlton and J. Weinman and R. Campbell",
year = "2010",
month = "8",
doi = "10.1007/s00125-010-1743-7",
language = "English",
volume = "53",
pages = "1590--1598",
journal = "DIABETOLOGIA",
issn = "0012-186X",
publisher = "Springer Berlin / Heidelberg",
number = "8",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Coping style and depression influence the healing of diabetic foot ulcers

T2 - DIABETOLOGIA

AU - Vedhara, K.

AU - Miles, J. N. V.

AU - Wetherell, M. A.

AU - Dawe, K.

AU - Searle, A.

AU - Tallon, D.

AU - Cullum, N.

AU - Day, A.

AU - Dayan, C.

AU - Drake, N.

AU - Price, P.

AU - Tarlton, J.

AU - Weinman, J.

AU - Campbell, R.

PY - 2010/8

Y1 - 2010/8

N2 - Experimental evidence suggests that the healing of diabetic foot ulcers is affected by psychosocial factors such as distress. We examined this proposal in a prospective study, in which we considered the role of psychological distress and coping style in the healing of diabetic foot ulcers over a 24 week period. We also explored the role of salivary cortisol and matrix metalloproteinases (MMPs) as potential mechanisms.For this prospective observational study we recruited 93 (68 men; mean age 60 years) patients with neuropathic or neuroischaemic diabetic foot ulcers from specialist podiatry clinics in secondary care. Clinical and demographic determinants of healing, psychological distress, coping, salivary cortisol and both MMP2 and MMP9 were assessed at baseline. Ulcers were assessed at baseline and at 6, 12 and 24 weeks post-baseline. The primary outcome was ulcer status at 24 weeks, i.e. healed vs not healed.After controlling for clinical and demographic determinants of healing, ulcer healing at 24 weeks was predicted by confrontation coping, but not by depression or anxiety. Patients with unhealed ulcers exhibited greater confrontation coping (model including depression: OR 0.809, 95% CI 0.704-0.929, p = 0.003; model including anxiety: OR 0.810, 95% CI 0.704-0.930, p = 0.003). However, change in ulcer size over the observation period was associated with depression only (p = 0.04, d = 0.31). Healed ulcers by 24 weeks were also associated with lower evening cortisol, higher precursor MMP2 and a greater cortisol awakening response.Confrontation coping and depression predict ulcer healing. Our preliminary enquiry into biological mechanisms suggests that cortisol and precursor MMP2 may underlie these relationships.

AB - Experimental evidence suggests that the healing of diabetic foot ulcers is affected by psychosocial factors such as distress. We examined this proposal in a prospective study, in which we considered the role of psychological distress and coping style in the healing of diabetic foot ulcers over a 24 week period. We also explored the role of salivary cortisol and matrix metalloproteinases (MMPs) as potential mechanisms.For this prospective observational study we recruited 93 (68 men; mean age 60 years) patients with neuropathic or neuroischaemic diabetic foot ulcers from specialist podiatry clinics in secondary care. Clinical and demographic determinants of healing, psychological distress, coping, salivary cortisol and both MMP2 and MMP9 were assessed at baseline. Ulcers were assessed at baseline and at 6, 12 and 24 weeks post-baseline. The primary outcome was ulcer status at 24 weeks, i.e. healed vs not healed.After controlling for clinical and demographic determinants of healing, ulcer healing at 24 weeks was predicted by confrontation coping, but not by depression or anxiety. Patients with unhealed ulcers exhibited greater confrontation coping (model including depression: OR 0.809, 95% CI 0.704-0.929, p = 0.003; model including anxiety: OR 0.810, 95% CI 0.704-0.930, p = 0.003). However, change in ulcer size over the observation period was associated with depression only (p = 0.04, d = 0.31). Healed ulcers by 24 weeks were also associated with lower evening cortisol, higher precursor MMP2 and a greater cortisol awakening response.Confrontation coping and depression predict ulcer healing. Our preliminary enquiry into biological mechanisms suggests that cortisol and precursor MMP2 may underlie these relationships.

KW - Coping

KW - Cortisol

KW - Depression

KW - Diabetic foot ulcers

KW - Healing

KW - MMPs

KW - Prospective

KW - Psychological distress

KW - TRANSMISSION DENSITOMETRY

KW - GLYCEMIC CONTROL

KW - CHRONIC WOUNDS

KW - STRESS

KW - CORTISOL

KW - COHORT

KW - POPULATION

KW - PROGRESSION

KW - EXPRESSION

KW - MELLITUS

UR - http://www.scopus.com/inward/record.url?scp=77955516959&partnerID=8YFLogxK

U2 - 10.1007/s00125-010-1743-7

DO - 10.1007/s00125-010-1743-7

M3 - Article

VL - 53

SP - 1590

EP - 1598

JO - DIABETOLOGIA

JF - DIABETOLOGIA

SN - 0012-186X

IS - 8

ER -