TY - JOUR
T1 - Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation
AU - Moody, Catherine L.
AU - Franckevicius, Vilius
AU - Drouhin, Pauline
AU - Klein, Johannes E. M. N.
AU - Taylor, Richard J. K.
PY - 2012/4/11
Y1 - 2012/4/11
N2 - A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.
AB - A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.
UR - http://www.scopus.com/inward/record.url?scp=84858159365&partnerID=8YFLogxK
U2 - 10.1016/j.tetlet.2012.01.120
DO - 10.1016/j.tetlet.2012.01.120
M3 - Article
SN - 0040-4039
VL - 53
SP - 1897
EP - 1899
JO - Tetrahedron Letters
JF - Tetrahedron Letters
IS - 15
ER -