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Copper(I) reactions in N-heterocycle synthesis: efficient preparation of substituted pyrrolidinones

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Publication details

JournalTetrahedron Letters
DatePublished - 3 Dec 1999
Issue number49
Number of pages4
Pages (from-to)8615-8618
Original languageEnglish


Reaction of halo-enamides with copper(I) chloride in boiling toluene has been shown to produce unsaturated pyrrolidinones in excellent yield (81-94%). Both di- and trichloroamide precursors can be used to form dienes via an initial 5-endo-trig radical cyclisation. (C) 1999 Elsevier Science Ltd. All rights reserved.

    Research areas

  • copper, copper compounds, radicals, radical reactions, cyclisation, enamides, RADICAL CYCLIZATIONS, TEMPERATURE, SKELETON, LACTAMS

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