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Cortical lamina-dependent blood volume changes in human brain at 7 T

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Cortical lamina-dependent blood volume changes in human brain at 7 T. / Huber, Laurentius; Goense, Jozien; Kennerley, Aneurin J; Trampel, Robert; Guidi, Maria; Reimer, Enrico; Ivanov, Dimo; Neef, Nicole; Gauthier, Claudine J; Turner, Robert; Möller, Harald E.

In: Neuroimage, Vol. 107, 15.02.2015, p. 23-33.

Research output: Contribution to journalArticlepeer-review

Harvard

Huber, L, Goense, J, Kennerley, AJ, Trampel, R, Guidi, M, Reimer, E, Ivanov, D, Neef, N, Gauthier, CJ, Turner, R & Möller, HE 2015, 'Cortical lamina-dependent blood volume changes in human brain at 7 T', Neuroimage, vol. 107, pp. 23-33. https://doi.org/10.1016/j.neuroimage.2014.11.046

APA

Huber, L., Goense, J., Kennerley, A. J., Trampel, R., Guidi, M., Reimer, E., Ivanov, D., Neef, N., Gauthier, C. J., Turner, R., & Möller, H. E. (2015). Cortical lamina-dependent blood volume changes in human brain at 7 T. Neuroimage, 107, 23-33. https://doi.org/10.1016/j.neuroimage.2014.11.046

Vancouver

Huber L, Goense J, Kennerley AJ, Trampel R, Guidi M, Reimer E et al. Cortical lamina-dependent blood volume changes in human brain at 7 T. Neuroimage. 2015 Feb 15;107:23-33. https://doi.org/10.1016/j.neuroimage.2014.11.046

Author

Huber, Laurentius ; Goense, Jozien ; Kennerley, Aneurin J ; Trampel, Robert ; Guidi, Maria ; Reimer, Enrico ; Ivanov, Dimo ; Neef, Nicole ; Gauthier, Claudine J ; Turner, Robert ; Möller, Harald E. / Cortical lamina-dependent blood volume changes in human brain at 7 T. In: Neuroimage. 2015 ; Vol. 107. pp. 23-33.

Bibtex - Download

@article{e8deb65b73d14985974ea88c47607f56,
title = "Cortical lamina-dependent blood volume changes in human brain at 7 T",
abstract = "Cortical layer-dependent high (sub-millimeter) resolution functional magnetic resonance imaging (fMRI) in human or animal brain can be used to address questions regarding the functioning of cortical circuits, such as the effect of different afferent and efferent connectivities on activity in specific cortical layers. The sensitivity of gradient echo (GE) blood oxygenation level-dependent (BOLD) responses to large draining veins reduces its local specificity and can render the interpretation of the underlying laminar neural activity impossible. The application of the more spatially specific cerebral blood volume (CBV)-based fMRI in humans has been hindered by the low sensitivity of the noninvasive modalities available. Here, a vascular space occupancy (VASO) variant, adapted for use at high field, is further optimized to capture layer-dependent activity changes in human motor cortex at sub-millimeter resolution. Acquired activation maps and cortical profiles show that the VASO signal peaks in gray matter at 0.8-1.6mm depth, and deeper compared to the superficial and vein-dominated GE-BOLD responses. Validation of the VASO signal change versus well-established iron-oxide contrast agent based fMRI methods in animals showed the same cortical profiles of CBV change, after normalization for lamina-dependent baseline CBV. In order to evaluate its potential of revealing small lamina-dependent signal differences due to modulations of the input-output characteristics, layer-dependent VASO responses were investigated in the ipsilateral hemisphere during unilateral finger tapping. Positive activation in ipsilateral primary motor cortex and negative activation in ipsilateral primary sensory cortex were observed. This feature is only visible in high-resolution fMRI where opposing sides of a sulcus can be investigated independently because of a lack of partial volume effects. Based on the results presented here, we conclude that VASO offers good reproducibility, high sensitivity and lower sensitivity than GE-BOLD to changes in larger vessels, making it a valuable tool for layer-dependent fMRI studies in humans.",
keywords = "Adult, Algorithms, Animals, Blood Vessels, Blood Volume, Brain, Cerebral Cortex, Cerebrovascular Circulation, Efferent Pathways, Female, Ferric Compounds, Fingers, Haplorhini, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging, Male, Motor Cortex, Movement, Oxygen, Rats, Signal-To-Noise Ratio, Young Adult, Journal Article, Research Support, Non-U.S. Gov't",
author = "Laurentius Huber and Jozien Goense and Kennerley, {Aneurin J} and Robert Trampel and Maria Guidi and Enrico Reimer and Dimo Ivanov and Nicole Neef and Gauthier, {Claudine J} and Robert Turner and M{\"o}ller, {Harald E}",
note = "Copyright {\textcopyright} 2014 Elsevier Inc. All rights reserved.",
year = "2015",
month = feb,
day = "15",
doi = "10.1016/j.neuroimage.2014.11.046",
language = "English",
volume = "107",
pages = "23--33",
journal = "Neuroimage",
issn = "1053-8119",
publisher = "Academic Press Inc.",

}

RIS (suitable for import to EndNote) - Download

TY - JOUR

T1 - Cortical lamina-dependent blood volume changes in human brain at 7 T

AU - Huber, Laurentius

AU - Goense, Jozien

AU - Kennerley, Aneurin J

AU - Trampel, Robert

AU - Guidi, Maria

AU - Reimer, Enrico

AU - Ivanov, Dimo

AU - Neef, Nicole

AU - Gauthier, Claudine J

AU - Turner, Robert

AU - Möller, Harald E

N1 - Copyright © 2014 Elsevier Inc. All rights reserved.

PY - 2015/2/15

Y1 - 2015/2/15

N2 - Cortical layer-dependent high (sub-millimeter) resolution functional magnetic resonance imaging (fMRI) in human or animal brain can be used to address questions regarding the functioning of cortical circuits, such as the effect of different afferent and efferent connectivities on activity in specific cortical layers. The sensitivity of gradient echo (GE) blood oxygenation level-dependent (BOLD) responses to large draining veins reduces its local specificity and can render the interpretation of the underlying laminar neural activity impossible. The application of the more spatially specific cerebral blood volume (CBV)-based fMRI in humans has been hindered by the low sensitivity of the noninvasive modalities available. Here, a vascular space occupancy (VASO) variant, adapted for use at high field, is further optimized to capture layer-dependent activity changes in human motor cortex at sub-millimeter resolution. Acquired activation maps and cortical profiles show that the VASO signal peaks in gray matter at 0.8-1.6mm depth, and deeper compared to the superficial and vein-dominated GE-BOLD responses. Validation of the VASO signal change versus well-established iron-oxide contrast agent based fMRI methods in animals showed the same cortical profiles of CBV change, after normalization for lamina-dependent baseline CBV. In order to evaluate its potential of revealing small lamina-dependent signal differences due to modulations of the input-output characteristics, layer-dependent VASO responses were investigated in the ipsilateral hemisphere during unilateral finger tapping. Positive activation in ipsilateral primary motor cortex and negative activation in ipsilateral primary sensory cortex were observed. This feature is only visible in high-resolution fMRI where opposing sides of a sulcus can be investigated independently because of a lack of partial volume effects. Based on the results presented here, we conclude that VASO offers good reproducibility, high sensitivity and lower sensitivity than GE-BOLD to changes in larger vessels, making it a valuable tool for layer-dependent fMRI studies in humans.

AB - Cortical layer-dependent high (sub-millimeter) resolution functional magnetic resonance imaging (fMRI) in human or animal brain can be used to address questions regarding the functioning of cortical circuits, such as the effect of different afferent and efferent connectivities on activity in specific cortical layers. The sensitivity of gradient echo (GE) blood oxygenation level-dependent (BOLD) responses to large draining veins reduces its local specificity and can render the interpretation of the underlying laminar neural activity impossible. The application of the more spatially specific cerebral blood volume (CBV)-based fMRI in humans has been hindered by the low sensitivity of the noninvasive modalities available. Here, a vascular space occupancy (VASO) variant, adapted for use at high field, is further optimized to capture layer-dependent activity changes in human motor cortex at sub-millimeter resolution. Acquired activation maps and cortical profiles show that the VASO signal peaks in gray matter at 0.8-1.6mm depth, and deeper compared to the superficial and vein-dominated GE-BOLD responses. Validation of the VASO signal change versus well-established iron-oxide contrast agent based fMRI methods in animals showed the same cortical profiles of CBV change, after normalization for lamina-dependent baseline CBV. In order to evaluate its potential of revealing small lamina-dependent signal differences due to modulations of the input-output characteristics, layer-dependent VASO responses were investigated in the ipsilateral hemisphere during unilateral finger tapping. Positive activation in ipsilateral primary motor cortex and negative activation in ipsilateral primary sensory cortex were observed. This feature is only visible in high-resolution fMRI where opposing sides of a sulcus can be investigated independently because of a lack of partial volume effects. Based on the results presented here, we conclude that VASO offers good reproducibility, high sensitivity and lower sensitivity than GE-BOLD to changes in larger vessels, making it a valuable tool for layer-dependent fMRI studies in humans.

KW - Adult

KW - Algorithms

KW - Animals

KW - Blood Vessels

KW - Blood Volume

KW - Brain

KW - Cerebral Cortex

KW - Cerebrovascular Circulation

KW - Efferent Pathways

KW - Female

KW - Ferric Compounds

KW - Fingers

KW - Haplorhini

KW - Humans

KW - Image Processing, Computer-Assisted

KW - Magnetic Resonance Imaging

KW - Male

KW - Motor Cortex

KW - Movement

KW - Oxygen

KW - Rats

KW - Signal-To-Noise Ratio

KW - Young Adult

KW - Journal Article

KW - Research Support, Non-U.S. Gov't

U2 - 10.1016/j.neuroimage.2014.11.046

DO - 10.1016/j.neuroimage.2014.11.046

M3 - Article

C2 - 25479018

VL - 107

SP - 23

EP - 33

JO - Neuroimage

JF - Neuroimage

SN - 1053-8119

ER -