Cost-effectiveness of COVID-19 vaccination in Latin America and the Caribbean: an analysis in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru

Federico Augustovski; Ariel Bardach; Adrián Santoro; Federico Rodriguez-Cairoli; Alejandro López-Osornio; Fernando Argento; Maissa Havela; Alejandro Blumenfeld; Jamile Ballivian; Germán Solioz; Analía Capula; Analía López; Cintia Cejas; William Savedoff; Alfredo Palacios; Adolfo Rubinstein; Andrés Pichon-Riviere

doi:10.1186/s12962-023-00430-2

Cost-effectiveness of COVID-19 vaccination in Latin America and the Caribbean: an analysis in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru

Federico Augustovski, Ariel Bardach, Adrián Santoro, Federico Rodriguez-Cairoli, Alejandro López-Osornio, Fernando Argento, Maissa Havela, Alejandro Blumenfeld, Jamile Ballivian, Germán Solioz, Analía Capula, Analía López, Cintia Cejas, William Savedoff, Alfredo Palacios, Adolfo Rubinstein, Andrés Pichon-Riviere

Centre for Health Economics

Research output: Contribution to journal › Article › peer-review

Abstract

OBJECTIVE: Our study analyzes the cost-effectiveness of the COVID-19 vaccination campaigns in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru.

METHODS: Using a previously published SVEIR model, we analyzed the impact of a vaccination campaign (2021) from a national healthcare perspective. The primary outcomes were quality adjusted life years (QALYs) lost and total costs. Other outcomes included COVID-19 cases, hospitalizations, deaths, and life years. We applied a discount rate of 3% for health outcomes. We modeled a realistic vaccination campaign in each country (the realistic country-specific campaign). Additionally, we assessed a standard campaign (similar, "typical" for all countries), and an optimized campaign (similar in all countries with higher but plausible population coverage). One-way deterministic sensitivity analyses were performed.

FINDINGS: Vaccination was health improving as well as cost-saving in almost all countries and scenarios. Our analysis shows that vaccination in this group of countries prevented 573,141 deaths (508,826 standard; 685,442 optimized) and gained 5.07 million QALYs (4.53 standard; 6.03 optimized). Despite the incremental costs of vaccination campaigns, they had a total net cost saving to the health system of US$16.29 billion (US$16.47 standard; US$18.58 optimized). The realistic (base case) vaccination campaign in Chile was the only scenario, which was not cost saving, but it was still highly cost-effective with an ICER of US$22 per QALY gained. Main findings were robust in the sensitivity analyses.

INTERPRETATION: The COVID-19 vaccination campaign in seven Latin American and Caribbean countries -that comprise nearly 80% of the region- was beneficial for population health and was also cost-saving or highly cost-effective.

Original language	English
Article number	21
Pages (from-to)	21
Number of pages	13
Journal	Cost Effectiveness and Resource Allocation
Volume	21
Issue number	1
DOIs	https://doi.org/10.1186/s12962-023-00430-2 https://doi.org/10.1186/s12962-023-00430-2
Publication status	Published - 1 Apr 2023

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s12962-023-00430-2
© The Author(s) 2023
Final published version, 1.04 MBLicence: CC BY

Cite this

Augustovski, F., Bardach, A., Santoro, A., Rodriguez-Cairoli, F., López-Osornio, A., Argento, F., Havela, M., Blumenfeld, A., Ballivian, J., Solioz, G., Capula, A., López, A., Cejas, C., Savedoff, W., Palacios, A., Rubinstein, A., & Pichon-Riviere, A. (2023). Cost-effectiveness of COVID-19 vaccination in Latin America and the Caribbean: an analysis in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru. Cost Effectiveness and Resource Allocation, 21(1), 21. Article 21. https://doi.org/10.1186/s12962-023-00430-2, https://doi.org/10.1186/s12962-023-00430-2

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Augustovski, F, Bardach, A, Santoro, A, Rodriguez-Cairoli, F, López-Osornio, A, Argento, F, Havela, M, Blumenfeld, A, Ballivian, J, Solioz, G, Capula, A, López, A, Cejas, C, Savedoff, W, Palacios, A, Rubinstein, A & Pichon-Riviere, A 2023, 'Cost-effectiveness of COVID-19 vaccination in Latin America and the Caribbean: an analysis in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru', Cost Effectiveness and Resource Allocation, vol. 21, no. 1, 21, pp. 21. https://doi.org/10.1186/s12962-023-00430-2, https://doi.org/10.1186/s12962-023-00430-2

Cost-effectiveness of COVID-19 vaccination in Latin America and the Caribbean: an analysis in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru. / Augustovski, Federico; Bardach, Ariel; Santoro, Adrián et al.
In: Cost Effectiveness and Resource Allocation, Vol. 21, No. 1, 21, 01.04.2023, p. 21.

Research output: Contribution to journal › Article › peer-review

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AU - Augustovski, Federico

AU - Bardach, Ariel

AU - Santoro, Adrián

AU - Rodriguez-Cairoli, Federico

AU - López-Osornio, Alejandro

AU - Argento, Fernando

AU - Havela, Maissa

AU - Blumenfeld, Alejandro

AU - Ballivian, Jamile

AU - Solioz, Germán

AU - Capula, Analía

AU - López, Analía

AU - Cejas, Cintia

AU - Savedoff, William

AU - Palacios, Alfredo

AU - Rubinstein, Adolfo

AU - Pichon-Riviere, Andrés

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N2 - OBJECTIVE: Our study analyzes the cost-effectiveness of the COVID-19 vaccination campaigns in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru.METHODS: Using a previously published SVEIR model, we analyzed the impact of a vaccination campaign (2021) from a national healthcare perspective. The primary outcomes were quality adjusted life years (QALYs) lost and total costs. Other outcomes included COVID-19 cases, hospitalizations, deaths, and life years. We applied a discount rate of 3% for health outcomes. We modeled a realistic vaccination campaign in each country (the realistic country-specific campaign). Additionally, we assessed a standard campaign (similar, "typical" for all countries), and an optimized campaign (similar in all countries with higher but plausible population coverage). One-way deterministic sensitivity analyses were performed.FINDINGS: Vaccination was health improving as well as cost-saving in almost all countries and scenarios. Our analysis shows that vaccination in this group of countries prevented 573,141 deaths (508,826 standard; 685,442 optimized) and gained 5.07 million QALYs (4.53 standard; 6.03 optimized). Despite the incremental costs of vaccination campaigns, they had a total net cost saving to the health system of US$16.29 billion (US$16.47 standard; US$18.58 optimized). The realistic (base case) vaccination campaign in Chile was the only scenario, which was not cost saving, but it was still highly cost-effective with an ICER of US$22 per QALY gained. Main findings were robust in the sensitivity analyses.INTERPRETATION: The COVID-19 vaccination campaign in seven Latin American and Caribbean countries -that comprise nearly 80% of the region- was beneficial for population health and was also cost-saving or highly cost-effective.

AB - OBJECTIVE: Our study analyzes the cost-effectiveness of the COVID-19 vaccination campaigns in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru.METHODS: Using a previously published SVEIR model, we analyzed the impact of a vaccination campaign (2021) from a national healthcare perspective. The primary outcomes were quality adjusted life years (QALYs) lost and total costs. Other outcomes included COVID-19 cases, hospitalizations, deaths, and life years. We applied a discount rate of 3% for health outcomes. We modeled a realistic vaccination campaign in each country (the realistic country-specific campaign). Additionally, we assessed a standard campaign (similar, "typical" for all countries), and an optimized campaign (similar in all countries with higher but plausible population coverage). One-way deterministic sensitivity analyses were performed.FINDINGS: Vaccination was health improving as well as cost-saving in almost all countries and scenarios. Our analysis shows that vaccination in this group of countries prevented 573,141 deaths (508,826 standard; 685,442 optimized) and gained 5.07 million QALYs (4.53 standard; 6.03 optimized). Despite the incremental costs of vaccination campaigns, they had a total net cost saving to the health system of US$16.29 billion (US$16.47 standard; US$18.58 optimized). The realistic (base case) vaccination campaign in Chile was the only scenario, which was not cost saving, but it was still highly cost-effective with an ICER of US$22 per QALY gained. Main findings were robust in the sensitivity analyses.INTERPRETATION: The COVID-19 vaccination campaign in seven Latin American and Caribbean countries -that comprise nearly 80% of the region- was beneficial for population health and was also cost-saving or highly cost-effective.

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DO - 10.1186/s12962-023-00430-2

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Augustovski F, Bardach A, Santoro A, Rodriguez-Cairoli F, López-Osornio A, Argento F et al. Cost-effectiveness of COVID-19 vaccination in Latin America and the Caribbean: an analysis in Argentina, Brazil, Chile, Colombia, Costa Rica, Mexico, and Peru. Cost Effectiveness and Resource Allocation. 2023 Apr 1;21(1):21. 21. doi: 10.1186/s12962-023-00430-2, 10.1186/s12962-023-00430-2