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Coupling between gamma-band power and cerebral blood volume during recurrent acute neocortical seizures

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Author(s)

  • Sam Harris
  • Hongtao Ma
  • Mingrui Zhao
  • Luke W Boorman
  • Ying Zheng
  • Aneurin Kennerley
  • Michael Bruyns-Haylett
  • Paul G Overton
  • Jason Berwick
  • Theodore H Schwartz

Department/unit(s)

Publication details

JournalNeuroimage
DateAccepted/In press - 2 Apr 2014
DateE-pub ahead of print - 13 Apr 2014
DatePublished (current) - 15 Aug 2014
Volume97
Number of pages9
Pages (from-to)62-70
Early online date13/04/14
Original languageEnglish

Abstract

Characterization of neural and hemodynamic biomarkers of epileptic activity that can be measured using non-invasive techniques is fundamental to the accurate identification of the epileptogenic zone (EZ) in the clinical setting. Recently, oscillations at gamma-band frequencies and above (>30 Hz) have been suggested to provide valuable localizing information of the EZ and track cortical activation associated with epileptogenic processes. Although a tight coupling between gamma-band activity and hemodynamic-based signals has been consistently demonstrated in non-pathological conditions, very little is known about whether such a relationship is maintained in epilepsy and the laminar etiology of these signals. Confirmation of this relationship may elucidate the underpinnings of perfusion-based signals in epilepsy and the potential value of localizing the EZ using hemodynamic correlates of pathological rhythms. Here, we use concurrent multi-depth electrophysiology and 2-dimensional optical imaging spectroscopy to examine the coupling between multi-band neural activity and cerebral blood volume (CBV) during recurrent acute focal neocortical seizures in the urethane-anesthetized rat. We show a powerful correlation between gamma-band power (25-90 Hz) and CBV across cortical laminae, in particular layer 5, and a close association between gamma measures and multi-unit activity (MUA). Our findings provide insights into the laminar electrophysiological basis of perfusion-based imaging signals in the epileptic state and may have implications for further research using non-invasive multi-modal techniques to localize epileptogenic tissue.

    Research areas

  • 4-Aminopyridine, Animals, Blood Volume, Cerebrovascular Circulation, Convulsants, Electroencephalography, Female, Gamma Rhythm, Neocortex, Optical Imaging, Rats, Recurrence, Seizures, Journal Article, Research Support, Non-U.S. Gov't

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