Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE

Simon Duckett; Gary George Reginald Green; Maria Alexandra Olaru; Soumya Singha Roy; Lyrelle Stacey Lloyd; Steven Coombes

doi:10.1039/C6CC02020H

Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE

Simon Duckett, Gary George Reginald Green, Maria Alexandra Olaru, Soumya Singha Roy, Lyrelle Stacey Lloyd, Steven Coombes

Research output: Contribution to journal › Article › peer-review

Abstract

The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the Signal Amplification By Reversible Exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90 % efficiency into the new state, which in this case has a 27 second lifetime.

Original language	English
Number of pages	4
Journal	Chemical Communications
Early online date	31 May 2016
DOIs	https://doi.org/10.1039/C6CC02020H
Publication status	E-pub ahead of print - 31 May 2016

Bibliographical note

©The Royal Society of Chemistry 2016.

Access to Document

10.1039/C6CC02020HLicence: CC BY-NC

c6cc02020h
©The Royal Society of Chemistry 2016.
Final published version, 1.42 MBLicence: CC BY-NC

http://pubs.rsc.org/en/content/articlehtml/2016/cc/c6cc02020hLicence: CC BY

Hyperpolarisation using SABRE as a new tool for imaging
Duckett, S. B. (Principal investigator) & Green, G. G. R. (Co-investigator)
1/10/12 → 31/03/19
Project: Research project (funded) › Research

Data for the paper Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE
Duckett, S. B. (Creator), University of York, 26 May 2016
DOI: 10.15124/f0779356-a6f1-4c36-bac4-6fdf280ff6b2, https://webfiles.york.ac.uk/INFODATA/f0779356-a6f1-4c36-bac4-6fdf280ff6b2 and one more link, https://creativecommons.org/licenses/by/4.0/ (show fewer)
Dataset

Cite this

@article{fd078de9e6694c88b101ed8bd0c7dc40,

title = "Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE",

abstract = "The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the Signal Amplification By Reversible Exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90 % efficiency into the new state, which in this case has a 27 second lifetime. ",

author = "Simon Duckett and Green, {Gary George Reginald} and Olaru, {Maria Alexandra} and {Singha Roy}, Soumya and Lloyd, {Lyrelle Stacey} and Steven Coombes",

note = "{\textcopyright}The Royal Society of Chemistry 2016. ",

year = "2016",

month = may,

day = "31",

doi = "10.1039/C6CC02020H",

language = "English",

journal = "Chemical Communications",

issn = "1359-7345",

publisher = "The Royal Society of Chemistry",

}

TY - JOUR

T1 - Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE

AU - Duckett, Simon

AU - Green, Gary George Reginald

AU - Olaru, Maria Alexandra

AU - Singha Roy, Soumya

AU - Lloyd, Lyrelle Stacey

AU - Coombes, Steven

PY - 2016/5/31

Y1 - 2016/5/31

N2 - The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the Signal Amplification By Reversible Exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90 % efficiency into the new state, which in this case has a 27 second lifetime.

AB - The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the Signal Amplification By Reversible Exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90 % efficiency into the new state, which in this case has a 27 second lifetime.

U2 - 10.1039/C6CC02020H

DO - 10.1039/C6CC02020H

M3 - Article

SN - 1359-7345

JO - Chemical Communications

JF - Chemical Communications

ER -

Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE

Abstract

Bibliographical note

Access to Document

Projects

Hyperpolarisation using SABRE as a new tool for imaging

Datasets

Data for the paper Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE

Cite this