Projects per year
Abstract
The creation of magnetic states that have long lifetimes has been the subject of intense investigation, in part because of their potential to survive the time taken to travel from the point of injection in a patient to the point where a clinically diagnostic MRI trace is collected. We show here that it is possible to harness the Signal Amplification By Reversible Exchange (SABRE) process to create such states in a hyperpolarised form that improves their detectability in seconds without the need for any chemical change by reference to the model substrate 2-aminothiazole. We achieve this by transferring Zeeman derived polarisation that is 1500 times larger than that normally available at 400 MHz with greater than 90 % efficiency into the new state, which in this case has a 27 second lifetime.
Original language | English |
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Number of pages | 4 |
Journal | Chemical Communications |
Early online date | 31 May 2016 |
DOIs | |
Publication status | E-pub ahead of print - 31 May 2016 |
Bibliographical note
©The Royal Society of Chemistry 2016.Projects
- 1 Finished
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Hyperpolarisation using SABRE as a new tool for imaging
Duckett, S. B. & Green, G. G. R.
1/10/12 → 31/03/19
Project: Research project (funded) › Research
Datasets
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Data for the paper Creating a hyperpolarised pseudo singlet state through polarisation transfer from parahydrogen under SABRE
Duckett, S. B. (Creator), University of York, 26 May 2016
DOI: 10.15124/f0779356-a6f1-4c36-bac4-6fdf280ff6b2, https://webfiles.york.ac.uk/INFODATA/f0779356-a6f1-4c36-bac4-6fdf280ff6b2 and one more link, https://creativecommons.org/licenses/by/4.0/ (show fewer)
Dataset