CROSS-REACTIVITY BETWEEN NECATOR-AMERICANUS AND SCHISTOSOMA-MANSONI IN MICE

L M Timothy; P S Coulson; J M Behnke; R A Wilson

CROSS-REACTIVITY BETWEEN NECATOR-AMERICANUS AND SCHISTOSOMA-MANSONI IN MICE

L M Timothy, P S Coulson, J M Behnke, R A Wilson

Biology

Research output: Contribution to journal › Article › peer-review

Abstract

Poly-parasitism is common in endemic communities and reactivity of sera from hookworm-infected patients against schistosomular antigens has been reported. Protective cross-immunity between N. americanus and S. mansoni was investigated in NIH and BALB/c mice. Protective resistance to homologous challenge with both parasites was confirmed in this model, however, functional immunity to heterologous challenge was not demonstrated. Sera from animals which had received homologous challenge with N.americanus and from hookworm-infected mice, which had previously been exposed to radiation-attenuated S. mansoni, exhibited an enhanced IgGAM response to infective stage N. americanus somatic antigens. The implications of these results with respect to serodiagnosis are discussed.

Original language	English
Pages (from-to)	1143-1149
Number of pages	7
Journal	International Journal for Parasitology
Volume	22
Issue number	8
Publication status	Published - Dec 1992

Keywords

CROSS-REACTIVITY
NECATOR-AMERICANUS
SCHISTOSOMA-MANSONI
MICE
SERODIAGNOSIS
POLY-PARASITISM
HOOKWORM
INFECTION
EPIDEMIOLOGY
RESISTANCE
MIGRATION
CERCARIAE
ANTIGEN
LARVAE

Cite this

@article{e54539fed51f419ea2243d7bd765b5dd,

title = "CROSS-REACTIVITY BETWEEN NECATOR-AMERICANUS AND SCHISTOSOMA-MANSONI IN MICE",

abstract = "Poly-parasitism is common in endemic communities and reactivity of sera from hookworm-infected patients against schistosomular antigens has been reported. Protective cross-immunity between N. americanus and S. mansoni was investigated in NIH and BALB/c mice. Protective resistance to homologous challenge with both parasites was confirmed in this model, however, functional immunity to heterologous challenge was not demonstrated. Sera from animals which had received homologous challenge with N.americanus and from hookworm-infected mice, which had previously been exposed to radiation-attenuated S. mansoni, exhibited an enhanced IgGAM response to infective stage N. americanus somatic antigens. The implications of these results with respect to serodiagnosis are discussed.",

keywords = "CROSS-REACTIVITY, NECATOR-AMERICANUS, SCHISTOSOMA-MANSONI, MICE, SERODIAGNOSIS, POLY-PARASITISM, HOOKWORM, INFECTION, EPIDEMIOLOGY, RESISTANCE, MIGRATION, CERCARIAE, ANTIGEN, LARVAE",

author = "Timothy, {L M} and Coulson, {P S} and Behnke, {J M} and Wilson, {R A}",

year = "1992",

month = dec,

language = "English",

volume = "22",

pages = "1143--1149",

journal = "International Journal for Parasitology",

issn = "0020-7519",

publisher = "Elsevier",

number = "8",

}

TY - JOUR

T1 - CROSS-REACTIVITY BETWEEN NECATOR-AMERICANUS AND SCHISTOSOMA-MANSONI IN MICE

AU - Timothy, L M

AU - Coulson, P S

AU - Behnke, J M

AU - Wilson, R A

PY - 1992/12

Y1 - 1992/12

N2 - Poly-parasitism is common in endemic communities and reactivity of sera from hookworm-infected patients against schistosomular antigens has been reported. Protective cross-immunity between N. americanus and S. mansoni was investigated in NIH and BALB/c mice. Protective resistance to homologous challenge with both parasites was confirmed in this model, however, functional immunity to heterologous challenge was not demonstrated. Sera from animals which had received homologous challenge with N.americanus and from hookworm-infected mice, which had previously been exposed to radiation-attenuated S. mansoni, exhibited an enhanced IgGAM response to infective stage N. americanus somatic antigens. The implications of these results with respect to serodiagnosis are discussed.

AB - Poly-parasitism is common in endemic communities and reactivity of sera from hookworm-infected patients against schistosomular antigens has been reported. Protective cross-immunity between N. americanus and S. mansoni was investigated in NIH and BALB/c mice. Protective resistance to homologous challenge with both parasites was confirmed in this model, however, functional immunity to heterologous challenge was not demonstrated. Sera from animals which had received homologous challenge with N.americanus and from hookworm-infected mice, which had previously been exposed to radiation-attenuated S. mansoni, exhibited an enhanced IgGAM response to infective stage N. americanus somatic antigens. The implications of these results with respect to serodiagnosis are discussed.

KW - CROSS-REACTIVITY

KW - NECATOR-AMERICANUS

KW - SCHISTOSOMA-MANSONI

KW - MICE

KW - SERODIAGNOSIS

KW - POLY-PARASITISM

KW - HOOKWORM

KW - INFECTION

KW - EPIDEMIOLOGY

KW - RESISTANCE

KW - MIGRATION

KW - CERCARIAE

KW - ANTIGEN

KW - LARVAE

M3 - Article

VL - 22

SP - 1143

EP - 1149

JO - International Journal for Parasitology

JF - International Journal for Parasitology

SN - 0020-7519

IS - 8

ER -