By the same authors

From the same journal

Crystal structure of vipoxin at 2.0 Å: an example of regulation of a toxic function generated by molecular evolution

Research output: Contribution to journalArticle

Author(s)

  • M Perbandt
  • Julie C. Wilson
  • S Eschenburg
  • I Mancheva
  • B Aleksiev
  • N Genov
  • P Willingmann
  • W Weber
  • T.P Singh
  • Ch Betzel

Department/unit(s)

Publication details

JournalFEBS Letters
DatePublished - 4 Aug 1997
Issue number3
Volume412
Number of pages5
Pages (from-to)573-577
Original languageEnglish

Abstract

Vipoxin is the main toxic component in the venom of the Bulgarian snake Vipera ammodytes meridionalis, the most toxic snake in Europe. Vipoxin is a complex between a toxic phospholipase A2 (PLA2) and a non-toxic protein inhibitor. The structure is of genetic interest due to the high degree of sequence homology (62%) between the two functionally different components. The structure shows that the formation of the complex in vipoxin is significantly different to that seen in many known structures of phospholipases and contradicts the assumptions made in earlier studies. The modulation of PLA2 activity is of great pharmacological interest, and the present structure will be a model for structure-based drug design.

    Research areas

  • X-ray structure;, Synchrotron radiation;, Vipoxin;, PLA2-complex

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