Abstract
Vipoxin is the main toxic component in the venom of the Bulgarian snake Vipera ammodytes meridionalis, the most toxic snake in Europe, Vipoxin is a complex between a toxic phospholipase A(2) (PLA(2)) and a non-toxic protein inhibitor, The structure is of genetic interest due to the high degree of sequence homology (62%) between the two functionally different components, The structure shoes that the formation of the complex in vipoxin is significantly different to that seen in many known structures of phospholipases and contradicts the assumptions made in earlier studies, The modulation of PLA(2) activity is of great pharmacological interest, and the present structure will be a model for structure-based drug design. (C) 1997 Federation of European Biochemical Societies.
Original language | English |
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Pages (from-to) | 573-577 |
Number of pages | 5 |
Journal | FEBS Letters |
Volume | 412 |
Issue number | 3 |
Publication status | Published - 4 Aug 1997 |
Keywords
- X-ray structure
- synchrotron radiation
- vipoxin
- PLA(2)-complex
- DIMERIC PHOSPHOLIPASE-A2
- VENOM
- RESOLUTION
- INHIBITOR
- SEQUENCE
- COMPLEX