Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation

Konstantinos Chatzipanagis; Michele Iafisco; Teresa Roncal-Herrero; Matthew William Bilton; Anna Tampieri; Roland Kröger; Jose Manuel Delgado

doi:10.1039/C6CE00521G

Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation

Konstantinos Chatzipanagis, Michele Iafisco, Teresa Roncal-Herrero, Matthew William Bilton, Anna Tampieri, Roland Kröger, Jose Manuel Delgado

Physics

Research output: Contribution to journal › Article › peer-review

Abstract

This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situand ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.

Original language	English
Pages (from-to)	3170-3173
Number of pages	4
Journal	CrystEngComm
Volume	18
Early online date	7 Apr 2016
DOIs	https://doi.org/10.1039/C6CE00521G
Publication status	E-pub ahead of print - 7 Apr 2016

Bibliographical note

© The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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10.1039/C6CE00521G

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© The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
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Roland Kroger, FRMS
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12th Pacific Rim Conference on Ceramic and Glass Technology - Hawaii, US
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21 May 2017 → 26 May 2017
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Cite this

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title = "Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation",

abstract = "This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situand ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.",

author = "Konstantinos Chatzipanagis and Michele Iafisco and Teresa Roncal-Herrero and Bilton, {Matthew William} and Anna Tampieri and Roland Kr{\"o}ger and Delgado, {Jose Manuel}",

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AU - Chatzipanagis, Konstantinos

AU - Iafisco, Michele

AU - Roncal-Herrero, Teresa

AU - Bilton, Matthew William

AU - Tampieri, Anna

AU - Kröger, Roland

AU - Delgado, Jose Manuel

N1 - © The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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N2 - This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situand ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.

AB - This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situand ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.

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DO - 10.1039/C6CE00521G

M3 - Article

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EP - 3173

JO - CrystEngComm

JF - CrystEngComm

ER -

Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation

Abstract

Bibliographical note

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Roland Kroger, FRMS

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12th Pacific Rim Conference on Ceramic and Glass Technology - Hawaii, US

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