Crystallization of citrate-stabilized amorphous calcium phosphate to nanocrystalline apatite: a surface-mediated transformation

Konstantinos Chatzipanagis, Michele Iafisco, Teresa Roncal-Herrero, Matthew William Bilton, Anna Tampieri, Roland Kröger, Jose Manuel Delgado

Research output: Contribution to journalArticlepeer-review


This work explores the mechanisms underlying the crystallization of citrate-functionalized amorphous calcium phosphate (cit-ACP) in two relevant media, combining in situand ex situ characterization techniques. Results demonstrate that citrate desorption from cit-ACP triggers the surface-mediated transformation to nanocrystalline apatite (Ap). Our findings shed light on the key role of citrate, an important component of bone organic matrix, and the medium composition in controlling the rate of transformation and the morphology of the resulting Ap phase.
Original languageEnglish
Pages (from-to)3170-3173
Number of pages4
Early online date7 Apr 2016
Publication statusE-pub ahead of print - 7 Apr 2016

Bibliographical note

© The Royal Society of Chemistry 2016. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

Cite this