Crystallization of the GTP-dependent transcriptional regulator CodY from Bacillus subtilis

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Research output: Contribution to journal › Article

Published copy (DOI)

10.1107/S0907444902018358

Author(s)

E V Blagova
V M Levdikov
K Tachikawa
A L Sonenshein
A J Wilkinson

Department/unit(s)

Chemistry

Publication details

Journal	Acta Crystallographica Section D: Biological Crystallography
Date	Published - Jan 2003
Volume	59
Number of pages	3
Pages (from-to)	155-157
Original language	English

Abstract

CodY is a GTP sensor that represses transcription of early stationary phase and sporulation genes in Bacillus subtilis. As nutrients become limiting, GTP levels fall and CodY-mediated repression is relieved. Crystals of CodY have been grown in the presence and absence of GTP from sodium citrate buffered solutions containing lithium sulfate and diffraction data have been collected extending to 3.5 Angstrom spacing.

Research areas

NUTRITIONAL REPRESSION, EXPRESSION, OPERON, DEGRADATION, PROMOTER, PROTEINS

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