Cyclosulfamidate Mannose-Configured Cyclitol Allows Specific Allele-Dependent Inhibition of GH47 α-D-Mannosidases Through a Bump-Hole Strategy

Alexandra Males; Ken Kok; Alba Nin-Hill; Sija van den Beukel; Thomas J. M. Beenakker; Gijsbert A. van der Marel; Jeroen D. C. Codée; Herman S. Overkleeft; Carme Rovira; Gideon J. Davies; Marta Artola

doi:10.1039/d3sc05016e

Cyclosulfamidate Mannose-Configured Cyclitol Allows Specific Allele-Dependent Inhibition of GH47 α-D-Mannosidases Through a Bump-Hole Strategy

Alexandra Males, Ken Kok, Alba Nin-Hill, Sija van den Beukel, Thomas J. M. Beenakker, Gijsbert A. van der Marel, Jeroen D. C. Codée, Herman S. Overkleeft, Carme Rovira, Gideon J. Davies, Marta Artola

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	13581-13586
Number of pages	6
Journal	Chemical Science
Volume	14
DOIs	https://doi.org/10.1039/d3sc05016e
Publication status	Published - 17 Nov 2023

Bibliographical note

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10.1039/d3sc05016eLicence: CC BY

Trans-cyclosulfamidate mannose-configured cyclitol allows isoform-dependent inhibition of GH47 a-D-mannosidases through a bump–hole strategy†
© 2023 The Author(s)
Final published version, 911 KBLicence: CC BY

1 Finished
2 Active

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society
Davies, G. J.
EUROPEAN COMMISSION
1/06/21 → 31/05/27
Project: Research project (funded) › Research
RS Research Professorship
Davies, G. J.
THE ROYAL SOCIETY
1/01/17 → 31/12/27
Project: Research project (funded) › Research
Dissection of the Leishmania mannogen biosynthetic pathway: beta 1-2 mannan in pathogens and beyond
Davies, G. J.
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
20/01/20 → 19/04/23
Project: Research project (funded) › Research

Cite this

Males, A., Kok, K., Nin-Hill, A., Beukel, S. V. D., Beenakker, T. J. M., van der Marel, G. A., Codée, J. D. C., Overkleeft, H. S., Rovira, C., Davies, G. J., & Artola, M. (2023). Cyclosulfamidate Mannose-Configured Cyclitol Allows Specific Allele-Dependent Inhibition of GH47 α-D-Mannosidases Through a Bump-Hole Strategy. Chemical Science, 14, 13581-13586. https://doi.org/10.1039/d3sc05016e

@article{dc15fa4754ea45968a73a62e27e971ac,

title = "Cyclosulfamidate Mannose-Configured Cyclitol Allows Specific Allele-Dependent Inhibition of GH47 α-D-Mannosidases Through a Bump-Hole Strategy",

author = "Alexandra Males and Ken Kok and Alba Nin-Hill and Beukel, {Sija van den} and Beenakker, {Thomas J. M.} and {van der Marel}, {Gijsbert A.} and Cod{\'e}e, {Jeroen D. C.} and Overkleeft, {Herman S.} and Carme Rovira and Davies, {Gideon J.} and Marta Artola",

note = "{\textcopyright} 2023 The Author(s)",

year = "2023",

month = nov,

day = "17",

doi = "10.1039/d3sc05016e",

language = "English",

volume = "14",

pages = "13581--13586",

journal = "Chemical Science",

issn = "2041-6520",

publisher = "The Royal Society of Chemistry",

}

Males, A, Kok, K, Nin-Hill, A, Beukel, SVD, Beenakker, TJM, van der Marel, GA, Codée, JDC, Overkleeft, HS, Rovira, C, Davies, GJ & Artola, M 2023, 'Cyclosulfamidate Mannose-Configured Cyclitol Allows Specific Allele-Dependent Inhibition of GH47 α-D-Mannosidases Through a Bump-Hole Strategy', Chemical Science, vol. 14, pp. 13581-13586. https://doi.org/10.1039/d3sc05016e

TY - JOUR

T1 - Cyclosulfamidate Mannose-Configured Cyclitol Allows Specific Allele-Dependent Inhibition of GH47 α-D-Mannosidases Through a Bump-Hole Strategy

AU - Males, Alexandra

AU - Kok, Ken

AU - Nin-Hill, Alba

AU - Beukel, Sija van den

AU - Beenakker, Thomas J. M.

AU - van der Marel, Gijsbert A.

AU - Codée, Jeroen D. C.

AU - Overkleeft, Herman S.

AU - Rovira, Carme

AU - Davies, Gideon J.

AU - Artola, Marta

PY - 2023/11/17

Y1 - 2023/11/17

U2 - 10.1039/d3sc05016e

DO - 10.1039/d3sc05016e

M3 - Article

SN - 2041-6520

VL - 14

SP - 13581

EP - 13586

JO - Chemical Science

JF - Chemical Science

ER -

Cyclosulfamidate Mannose-Configured Cyclitol Allows Specific Allele-Dependent Inhibition of GH47 α-D-Mannosidases Through a Bump-Hole Strategy

Bibliographical note

Access to Document

Projects

CARBOCENTRE: Activity-Based Profiling of Glycoprocessing Enzymes for Human Health and a Sustainable Society

RS Research Professorship

Dissection of the Leishmania mannogen biosynthetic pathway: beta 1-2 mannan in pathogens and beyond

Cite this