Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-L-Arabinofuranosidase Inhibitor

Nicholas G. S. McGregor; Joan Coines; Valentina Borlandelli; Satoko Amaki; Marta Artola; Alba Nin‐Hill; Daniël Linzel; Chihaya Yamada; Takatoshi Arakawa; Akihiro Ishiwata; Yukishige Ito; Gijsbert A. van der Marel; Jeroen D. C. Codée; Shinya Fushinobu; Herman S. Overkleeft; Carme Rovira; Gideon J. Davies

doi:10.1002/anie.202013920

Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-L-Arabinofuranosidase Inhibitor

Nicholas G. S. McGregor, Joan Coines, Valentina Borlandelli, Satoko Amaki, Marta Artola, Alba Nin‐Hill, Daniël Linzel, Chihaya Yamada, Takatoshi Arakawa, Akihiro Ishiwata, Yukishige Ito, Gijsbert A. van der Marel, Jeroen D. C. Codée, Shinya Fushinobu, Herman S. Overkleeft, Carme Rovira, Gideon J. Davies

Chemistry

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	5754-5758
Number of pages	5
Journal	Angewandte Chemie International Edition
Volume	60
Issue number	11
Early online date	2 Feb 2021
DOIs	https://doi.org/10.1002/anie.202013920
Publication status	Published - 8 Mar 2021

Bibliographical note

© 2021 Wiley-VCH GmbH. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

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10.1002/anie.202013920

Author Accepted Version (was slightly subsequently modified at proof stage)
© 2021 Wiley-VCH GmbH. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details
Accepted author manuscript, 4.13 MB

1 Finished
1 Active

RS Research Professorship
Davies, G. J. (Principal investigator)
THE ROYAL SOCIETY
1/01/17 → 31/12/27
Project: Research project (funded) › Research
Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis
Davies, G. J. (Principal investigator)
BBSRC (BIOTECHNOLOGY AND BIOLOGICAL SCIENCES RESEARCH COUNCIL)
1/01/18 → 31/12/21
Project: Research project (funded) › Research

Cite this

McGregor, N. G. S., Coines, J., Borlandelli, V., Amaki, S., Artola, M., Nin‐Hill, A., Linzel, D., Yamada, C., Arakawa, T., Ishiwata, A., Ito, Y., van der Marel, G. A., Codée, J. D. C., Fushinobu, S., Overkleeft, H. S., Rovira, C., & Davies, G. J. (2021). Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-L-Arabinofuranosidase Inhibitor. Angewandte Chemie International Edition, 60(11), 5754-5758. https://doi.org/10.1002/anie.202013920

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title = "Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-L-Arabinofuranosidase Inhibitor",

author = "McGregor, {Nicholas G. S.} and Joan Coines and Valentina Borlandelli and Satoko Amaki and Marta Artola and Alba Nin‐Hill and Dani{\"e}l Linzel and Chihaya Yamada and Takatoshi Arakawa and Akihiro Ishiwata and Yukishige Ito and {van der Marel}, {Gijsbert A.} and Cod{\'e}e, {Jeroen D. C.} and Shinya Fushinobu and Overkleeft, {Herman S.} and Carme Rovira and Davies, {Gideon J.}",

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McGregor, NGS, Coines, J, Borlandelli, V, Amaki, S, Artola, M, Nin‐Hill, A, Linzel, D, Yamada, C, Arakawa, T, Ishiwata, A, Ito, Y, van der Marel, GA, Codée, JDC, Fushinobu, S, Overkleeft, HS, Rovira, C & Davies, GJ 2021, 'Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-L-Arabinofuranosidase Inhibitor', Angewandte Chemie International Edition, vol. 60, no. 11, pp. 5754-5758. https://doi.org/10.1002/anie.202013920

TY - JOUR

T1 - Cysteine Nucleophiles in Glycosidase Catalysis

T2 - Application of a Covalent β-L-Arabinofuranosidase Inhibitor

AU - McGregor, Nicholas G. S.

AU - Coines, Joan

AU - Borlandelli, Valentina

AU - Amaki, Satoko

AU - Artola, Marta

AU - Nin‐Hill, Alba

AU - Linzel, Daniël

AU - Yamada, Chihaya

AU - Arakawa, Takatoshi

AU - Ishiwata, Akihiro

AU - Ito, Yukishige

AU - van der Marel, Gijsbert A.

AU - Codée, Jeroen D. C.

AU - Fushinobu, Shinya

AU - Overkleeft, Herman S.

AU - Rovira, Carme

AU - Davies, Gideon J.

N1 - © 2021 Wiley-VCH GmbH. This is an author-produced version of the published paper. Uploaded in accordance with the publisher’s self-archiving policy. Further copying may not be permitted; contact the publisher for details

PY - 2021/3/8

Y1 - 2021/3/8

U2 - 10.1002/anie.202013920

DO - 10.1002/anie.202013920

M3 - Article

SN - 1433-7851

VL - 60

SP - 5754

EP - 5758

JO - Angewandte Chemie International Edition

JF - Angewandte Chemie International Edition

IS - 11

ER -

Cysteine Nucleophiles in Glycosidase Catalysis: Application of a Covalent β-L-Arabinofuranosidase Inhibitor

Bibliographical note

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Projects

RS Research Professorship

Application of activity-based glycosidase probes for mechanism, enzyme discovery and clinical diagnosis

Cite this