Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application

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The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up the rate of relaxation. Consequently, the lifetime over which the hyperpolarised contrast agent is visible is drastically reduced. We show that the addition of a chelating ligand, such as bipyridine, rapidly deactivates the SABRE catalyst thereby lengthening the agent's relaxation times and improving the potential of SABRE for diagnostic MRI.
Original languageEnglish
Pages (from-to)9857-9859
Number of pages3
JournalChemical Communications
Early online date13 May 2015
Publication statusPublished - 2015

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