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Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application
Research output: Contribution to journal › Article › peer-review
Author(s)
Department/unit(s)
Publication details
| Journal | Chemical Communications |
|---|---|
| Date | E-pub ahead of print - 13 May 2015 |
| Date | Published (current) - 2015 |
| Volume | 51 |
| Number of pages | 3 |
| Pages (from-to) | 9857-9859 |
| Early online date | 13/05/15 |
| Original language | English |
Abstract
The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up the rate of relaxation. Consequently, the lifetime over which the hyperpolarised contrast agent is visible is drastically reduced. We show that the addition of a chelating ligand, such as bipyridine, rapidly deactivates the SABRE catalyst thereby lengthening the agent's relaxation times and improving the potential of SABRE for diagnostic MRI.
Projects
Hyperpolarisation using SABRE as a new tool for imaging
Project: Research project (funded) › Research
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