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Deactivation of signal amplification by reversible exchange catalysis, progress towards in vivo application

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JournalChemical Communications
DateE-pub ahead of print - 13 May 2015
DatePublished (current) - 2015
Volume51
Number of pages3
Pages (from-to)9857-9859
Early online date13/05/15
Original languageEnglish

Abstract

The catalyst which is used in the signal amplification by reversible exchange (SABRE) process facilitates substrate hyperpolarisation while acting to speed up the rate of relaxation. Consequently, the lifetime over which the hyperpolarised contrast agent is visible is drastically reduced. We show that the addition of a chelating ligand, such as bipyridine, rapidly deactivates the SABRE catalyst thereby lengthening the agent's relaxation times and improving the potential of SABRE for diagnostic MRI.

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